Skip to main content

Brain Tumor Segmentation and Parsing on MRIs Using Multiresolution Neural Networks

  • Conference paper
  • First Online:
Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries (BrainLes 2017)

Abstract

Brain lesion segmentation is a critical application of computer vision to the biomedical image analysis. The difficulty is derived from the great variance between instances, and the high computational cost of processing three dimensional data. We introduce a neural network for brain tumor semantic segmentation that parses their internal structures and is capable of processing volumetric data from multiple MRI modalities simultaneously. As a result, the method is able to learn from small training datasets. We develop an architecture that has four parallel pathways with residual connections. It receives patches from images with different spatial resolutions and analyzes them independently. The results are then combined using fully-connected layers to obtain a semantic segmentation of the brain tumor. We evaluated our method using the 2017 BraTS Challenge dataset, reaching average dice coefficients of \(89\%\), \(88\%\) and \(86\%\) over the training, validation and test images, respectively.

L.S. Castillo, L.A, Daza, L.C. Rivera—Authors with equal contribution.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Mayo Clinic: Brain tumor - Symptoms and causes. http://www.mayoclinic.org/diseases-conditions/brain-tumor/symptoms-causes/dxc-20117134. Accessed 19 July 2017

  2. kinderkrebsinfo.de: Brain tumours - tumours of the central nervous system. https://www.kinderkrebsinfo.de/diseases/brain_tumours/index_eng.html. Accessed 24 Aug 2017

  3. The Royal Marsden NHS Foundation Trust: Glioma. https://www.royalmarsden.nhs.uk/your-care/cancer-types/paediatric-cancers/glioma. Accessed 24 Aug 2017

  4. Menze, B., Jakab, A., Bauer, S., Kalpathy-Cramer, J., Farahani, K., Kirby, J., Burren, Y., Porz, N., Slotboom, J., Wiest, R., Lanczi, L., Gerstner, E., Weber, M.A., Arbel, T., Avants, B., Ayache, N., Buendia, P., Collins, L., Cordier, N., Corso, J., Criminisi, A., Das, T., Delingette, H., Demiralp, C., Durst, C., Dojat, M., Doyle, S., Festa, J., Forbes, F., Geremia, E., Glocker, B., Golland, P., Guo, X., Hamamci, A., Iftekharuddin, K., Jena, R., John, N., Konukoglu, E., Lashkari, D., Antonio Mariz, J., Meier, R., Pereira, S., Precup, D., Price, S.J., Riklin-Raviv, T., Reza, S., Ryan, M., Schwartz, L., Shin, H.C., Shotton, J., Silva, C., Sousa, N., Subbanna, N., Szekely, G., Taylor, T., Thomas, O., Tustison, N., Unal, G., Vasseur, F., Wintermark, M., Hye Ye, D., Zhao, L., Zhao, B., Zikic, D., Prastawa, M., Reyes, M., Van Leemput, K.: The multimodal brain tumor image segmentation benchmark (BRATS). IEEE Trans. Med. Imaging 34(10), 1993–2024 (2015)

    Article  Google Scholar 

  5. Prastawa, M., Bullitt, E., Ho, S., Gerig, G.: A brain tumor segmentation framework based on outlier detection. Med. Image Anal. 8(3), 275–283 (2004)

    Article  Google Scholar 

  6. Parisot, S., Duffau, H., Chemouny, S., Paragios, N.: Joint tumor segmentation and dense deformable registration of brain MR images. In: Ayache, N., Delingette, H., Golland, P., Mori, K. (eds.) MICCAI 2012. LNCS, vol. 7511, pp. 651–658. Springer, Heidelberg (2012). https://doi.org/10.1007/978-3-642-33418-4_80

    Chapter  Google Scholar 

  7. Bauer, S., Fejes, T., Slotboom, J., Wiest, R., Nolte, L.P., Reyes, M.: Segmentation of brain tumor images based on integrated hierarchical classification and regularization. In: Proceedings MICCAI-BRATS (2012)

    Google Scholar 

  8. Menze, B.H., Geremia, E., Ayache, N., Szekely, G.: Segmenting glioma in multi-modal images using a generative-discriminative model for brain lesion segmentation. In: Proceedings MICCAI-BRATS (2012)

    Google Scholar 

  9. Zeiler, M.D., Fergus, R.: Visualizing and understanding convolutional networks. In: Fleet, D., Pajdla, T., Schiele, B., Tuytelaars, T. (eds.) ECCV 2014. LNCS, vol. 8689, pp. 818–833. Springer, Cham (2014). https://doi.org/10.1007/978-3-319-10590-1_53

    Google Scholar 

  10. Shelhamer, E., Long, J., Darrell, T.: Fully convolutional networks for semantic segmentation. CoRR abs/1605.06211 (2016)

    Google Scholar 

  11. Ronneberger, O., Fischer, P., Brox, T.: U-net: convolutional networks for biomedical image segmentation. CoRR abs/1505.04597 (2015)

    Google Scholar 

  12. Milletari, F., Navab, N., Ahmadi, S.: V-net: fully convolutional neural networks for volumetric medical image segmentation. CoRR abs/1606.04797 (2016)

    Google Scholar 

  13. Kamnitsas, K., Ferrante, E., Parisot, S., Ledig, C., Nori, A., Criminisi, A., Rueckert, D., Glocker, B.: Deepmedic on brain tumor segmentation. In: Proceedings of BRATS-MICCAI code, Athens, Greece. https://github.com/Kamnitsask/deepmedic

  14. Bakas, S., Akbari, H., Sotiras, A., Bilello, M., Rozycki, M., Kirby, J., Freymann, J., Farahani, K., Davatzikos, C.: Advancing the cancer genome atlas glioma MRI collections with expert segmentation labels and radiomic features. Nat. Sci. Data 4, 170117 (2017)

    Article  Google Scholar 

  15. Bakas, S., Akbari, H., Sotiras, A., Bilello, M., Rozycki, M., Kirby, J., Freymann, J., Farahani, K., Davatzikos, C.: Segmentation labels and radiomic features for the pre-operative scans of the TCGA-GBM collection. The Cancer Imaging Archive (2017). https://doi.org/10.7937/K9/TCIA.2017.KLXWJJ1Q

  16. Bakas, S., Akbari, H., Sotiras, A., Bilello, M., Rozycki, M., Kirby, J., Freymann, J., Farahani, K., Davatzikos, C.: Segmentation labels and radiomic features for the pre-operative scans of the TCGA-IGG collection. The Cancer Imaging Archive (2017). https://doi.org/10.7937/K9/TCIA.2017.GJQ7R0EF

  17. Simonyan, K., Zisserman, A.: Very deep convolutional networks for large-scale image recognition. arXiv preprint arXiv:1409.1556 (2014)

  18. Rote, G.: Computing the minimum hausdorff distance between two point sets on a line under translation. Inf. Process. Lett. 38(3), 123–127 (1991)

    Article  MathSciNet  MATH  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Laura Silvana Castillo , Laura Alexandra Daza or Luis Carlos Rivera .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Castillo, L.S., Daza, L.A., Rivera, L.C., Arbeláez, P. (2018). Brain Tumor Segmentation and Parsing on MRIs Using Multiresolution Neural Networks. In: Crimi, A., Bakas, S., Kuijf, H., Menze, B., Reyes, M. (eds) Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries. BrainLes 2017. Lecture Notes in Computer Science(), vol 10670. Springer, Cham. https://doi.org/10.1007/978-3-319-75238-9_29

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-75238-9_29

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-75237-2

  • Online ISBN: 978-3-319-75238-9

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics