Skip to main content

A Holonic Multi-agent Based Diagnostic Decision Support System for Computer-Aided History and Physical Examination

  • Conference paper
  • First Online:

Part of the book series: Lecture Notes in Computer Science ((LNAI,volume 10978))

Abstract

Available Medical Diagnosis systems (MDSs), including the state of the art, mainly focus on finding the perfect link between the patient’s medical history and their health knowledge. However, no matter how powerful they are in performing this action, it is always possible that the final strong deduction is based on some incomplete input. Prior to this process, a physician should literally perform the Differential Diagnosis (DDx), in which (S)he carefully listens to the symptoms explained by the patient, considers some potential diagnoses and then tries to gather enough evidence and supporting information to shrink the probability of the other candidates. In a patient encounter, this method is used in a process called the History and Physical examination (H&P). Only physicians and in some institutions, in order to compensate the shortage of the physicians, some specially trained nurses are qualified to perform this process. A system capable of guiding a focus H&P, however, will allow less experienced nurses to perform this process, and furthermore, can provide second opinions in critical cases. The DDx domain is in fact a holonic domain; hence, a MDS with holonic architecture could be able to perform this process. As the Holonic Medical Diagnosis System (HMDS), tends to cover the stages in the H&P, this system could also be added to available MDSs in order to provide them with the essential comprehensive input and allow their integration in the clinical workflow. This paper will demonstrate the performance of this system and concentrates on its learning process.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Notes

  1. 1.

    The Euclidean distance between the DDPs of the DRAs.

  2. 2.

    In HMDS, the communications are solely done via the blackboard systems [30] of the DSAs.

  3. 3.

    The Euclidean distance between the corresponding DDP and the diagnosis request.

  4. 4.

    The holon identifier of the DRA acting for the final diagnosis, which is already updated considering the new observation.

  5. 5.

    If a super-holon, which has originally not participated in the diagnosis process, realizes that the disease given as the final diagnosis matches one of its members, it will assign the reward −1 (penalty) to this member.

References

  1. Berner, E.: Clinical Decision Support Systems: Theory and Practice. Springer, New York (2016). https://doi.org/10.1007/978-0-387-38319-4

    Book  Google Scholar 

  2. Merriam-Webster: Differential Diagnosis. https://www.merriam-webster.com/dictionary/differential%20diagnosis

  3. Maude, J.: Differential diagnosis: the key to reducing diagnosis error, measuring diagnosis and a mechanism to reduce healthcare costs. Diagnosis 1(1), 107–109 (2014)

    Article  Google Scholar 

  4. Segen, J.: Concise Dictionary of Modern Medicine. McGraw-Hill, New York (2006)

    Google Scholar 

  5. IBM Watson Health. https://www.ibm.com/watson/health/

  6. Fisher, H., Tomlinson, A., Ramnarayan, P., Britto, J.: ISABEL: support with clinical decision making. Pediatr. Nurs. 15(7), 34–35 (2003)

    Article  Google Scholar 

  7. Saxena, M.: IBM Watson Progress and 2013 Roadmap. https://www.slideshare.net/manojsaxena2/ibm-watson-progress-and-roadmap-saxena/7-Watson_Healthcare_Products_1H_2013. Accessed 22 Mar 2018

  8. Riches, N., Panagioti, M., Alam, R., Cheraghi-Sohi, S., Campbell, S., Esmail, A., Bower, P.: The effectiveness of electronic differential diagnoses (DDX) generators: a systematic review and meta-analysis. PLoS One 11(3), e0148991 (2016)

    Article  Google Scholar 

  9. Yuan, M.: Watson and healthcare: how natural language processing and semantic search could revolutionize clinical decision support. https://www.ibm.com/developerworks/library/os-ind-watson/. Accessed 22 Mar 2018

  10. Graber, M.L., Mathew, A.: Performance of a web-based clinical diagnosis support system for internists. J. Gen. Intern. Med. 23(1), 37–40 (2008)

    Article  Google Scholar 

  11. Husain, I.: Why IBM’s artificial intelligence “Watson” could not replace a physician. In: iMedicalApps. https://www.imedicalapps.com/2011/02/ibm-watson-replace-physician-artificial-intelligence/. Accessed 22 Mar 2018

  12. Akbari, Z., Unland, R.: A holonic multi-agent system approach to differential diagnosis. In: Berndt, J.O., Petta, P., Unland, R. (eds.) MATES 2017. LNCS (LNAI), vol. 10413, pp. 272–290. Springer, Cham (2017). https://doi.org/10.1007/978-3-319-64798-2_17

    Chapter  Google Scholar 

  13. Wooldridge, M.: Chapter 9: Methodologies. In: An Introduction to MultiAgent Systems. Wiley (2009)

    Google Scholar 

  14. Lavendelis, E., Grundspenkis, J.: Open holonic multi-agent architecture for intelligent tutoring system development. In: Proceedings of the IADIS International Conference on Intelligent Systems and Agents (2008)

    Google Scholar 

  15. Koestler, A.: The Gost in the Machine. Hutchinson, Paris (1967)

    Google Scholar 

  16. Gerber, C., Siekmann, J., Vierke, G.: Holonic multi-agent systems. Technical report DFKI-RR-99-03, German Research Centre for Artificial Intelligence (1999)

    Google Scholar 

  17. Unland, R.: A holonic multi-agent system for robust, flexible, and reliable medical diagnosis. In: Meersman, R., Tari, Z. (eds.) OTM 2003. LNCS, vol. 2889, pp. 1017–1030. Springer, Heidelberg (2003). https://doi.org/10.1007/978-3-540-39962-9_97

    Chapter  Google Scholar 

  18. Shehory, O., Sycara, K., Chalasani, P., Jha, S.: Agent cloning: an approach to agent mobility and resource allocation. IEEE Commun. Mag. 36(7), 58–67 (1998)

    Article  Google Scholar 

  19. Rodriguez, S.: From analysis to design of holonic multi-agent systems: a framework, methodological guidelines and applications. Ph.D. thesis, University of Technology of Belfort-Montbéliard (2005)

    Google Scholar 

  20. Mayo Clinic. https://www.mayoclinic.org/

  21. University of North Carolina - School of Medicine, History and Physical Examination (H&P) Examples. https://www.med.unc.edu/medclerk/education/grading/history-and-physical-examination-h-p-examples

  22. Cochrane, J.: Metastatic lung cancer to the common bile duct presenting as obstructive jaundice. J. Hepatol. Gastrointest. Disord. 2(121) (2016). https://www.omicsonline.org/open-access/metastatic-lung-cancer-to-the-common-bile-duct-presenting-as-obstructivejaundice-jhgd-1000121.php?aid=69570

  23. Ester, M., Kriegel, H.-P., Sander, J., Xu, X.: A density-based algorithm for discovering clusters in large spatial databases with noise. In: Simoudis, E., Han, J., Fayyad, U. (eds.): Proceedings of the 2nd International Conference on Knowledge Discovery and Data Mining (KDD-1996), pp. 226–231 (1996)

    Google Scholar 

  24. Akbari, Z., Unland, R.: Automated determination of the input parameter of the DBSCAN based on outlier detection. In: Artificial Intelligence Applications and Innovations, IFIP Advances in Information and Communication Technology, vol. 475, pp. 280–291 (2016)

    Google Scholar 

  25. NIST/SEMATECH e-Handbook of Statistical Methods. http://www.itl.nist.gov/div898/handbook/. Accessed Jan 2018

  26. Lemaire, O., Paul, C., Zabraniecki, L.: Distal Madelung-Launois-Bensaude disease: an unusual differential diagnosis of acromalic arthritis. Clin. Exp. Rheumatol. 26, 351–353 (2008)

    Google Scholar 

  27. Palminteri, S., Lefebvre, G., Kilford, E., Blakemore, S.-J.: Confirmation bias in human reinforcement learning: evidence from counterfactual feedback processing. PLoS Comput. Biol. 13(8), e1005684 (2017)

    Article  Google Scholar 

  28. Kayes, D., Anna, K.: The Learning Advantage: Six Practices of Learning-Directed Leadership. Springer, London (2011). https://doi.org/10.1057/9780230305595

    Book  Google Scholar 

  29. Dewey, D.: Reinforcement learning and the reward engineering principle. In: 2014 AAAI Spring Symposium Series (2014)

    Google Scholar 

  30. Corkill, D.: Blackboard systems. AI Experts 6(9), 40–47 (1991)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Zohreh Akbari .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Akbari, Z., Unland, R. (2018). A Holonic Multi-agent Based Diagnostic Decision Support System for Computer-Aided History and Physical Examination. In: Demazeau, Y., An, B., Bajo, J., Fernández-Caballero, A. (eds) Advances in Practical Applications of Agents, Multi-Agent Systems, and Complexity: The PAAMS Collection. PAAMS 2018. Lecture Notes in Computer Science(), vol 10978. Springer, Cham. https://doi.org/10.1007/978-3-319-94580-4_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-94580-4_3

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-94579-8

  • Online ISBN: 978-3-319-94580-4

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics