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Integration of Immune Models Using Petri Nets

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Artificial Immune Systems (ICARIS 2004)

Part of the book series: Lecture Notes in Computer Science ((LNCS,volume 3239))

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Abstract

Immune system has unique defense mechanisms such as innate, humoral and cellular immunity. These immunities are closely related to prevent pathogens from spreading in host and to clear them effectively. To achieve those mechanisms, particular processes, such as clonal expansion, positive and negative selection, and somatic hypermutation and so on, have been evolved. These properties inspired people to open a new field, called artificial immune systems that mimics and modifies immune behaviors to invent new technologies in other fields. To explain immune mechanisms, many mathematical models focusing on one particular phenomenon were developed. We developed an integrated immune model that enables to understand immune responses as a whole and to find new emergent properties of the immune system that could not be seen in separate models. We used a continuous Petri net as modeling language, because of its easiness of modeling and analysis.

This work was supported by the Korean Systems Biology Research Grant (M1-0309-02-0002) from the Ministry of Science and Technology. We would like to thank CHUNG Moon Soul Center for BioInformation and BioElectronics and the IBM SUR program for providing research and computing facilities.

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Authors and Affiliations

  1. Department of BioSystems, KAIST, 373-1, Guseong-dong, Yuseong-gu, Daejon, 305-701, Republic of Korea

    Dokyun Na, Inho Park, Kwang H. Lee & Doheon Lee

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  1. Dokyun Na
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  2. Inho Park
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  3. Kwang H. Lee
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  4. Doheon Lee
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Editors and Affiliations

  1. Department of Mathematics and Computer Science, University of Catania, Viale A. Doria 6, 95125, Catania, Italy

    Giuseppe Nicosia  & Vincenzo Cutello  & 

  2. Computer Science Department, University College London, London, UK

    Peter J. Bentley

  3. Department of Electronics, University of York, YO10 5DD, Heslington, York, UK

    Jon Timmis

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© 2004 Springer-Verlag Berlin Heidelberg

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Na, D., Park, I., Lee, K.H., Lee, D. (2004). Integration of Immune Models Using Petri Nets. In: Nicosia, G., Cutello, V., Bentley, P.J., Timmis, J. (eds) Artificial Immune Systems. ICARIS 2004. Lecture Notes in Computer Science, vol 3239. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-30220-9_17

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  • DOI: https://doi.org/10.1007/978-3-540-30220-9_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-23097-7

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