Abstract
We present a dynamic, three-dimensional, composite model framework for vertebrate development. Our integrated model combines submodels that address length-scales from subcellular to tissues and organs in a unified framework. Interacting submodels include a discrete model derived from non-equilibrium statistical mechanics (Cellular Potts Model) and continuous reaction-diffusion models. A state diagram with associated rules and a set of ordinary differential equations model genetic regulation to define and control cell differentiation. We apply the model spatiotemporal bone patterning in the proximo-distal (from body towards digits) direction of developing avian limb.
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Chaturvedi, R., Huang, C., Izaguirre, J.A., Newman, S.A., Glazier, J.A., Alber, M. (2004). A Hybrid Discrete-Continuum Model for 3-D Skeletogenesis of the Vertebrate Limb. In: Sloot, P.M.A., Chopard, B., Hoekstra, A.G. (eds) Cellular Automata. ACRI 2004. Lecture Notes in Computer Science, vol 3305. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-30479-1_56
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DOI: https://doi.org/10.1007/978-3-540-30479-1_56
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