Abstract
Seizing the idea of system-level thinking and to approach automated network analysis the relational platform PheGe was generated. PheGe is a pilot scheme for virtual biology on a systemic (multi-cellular organism) level. It resembles a prototype of knowledge base platforms that organize data-driven interactions in a way that attack the problem of digital recording and simulation of cell-overlapping signal cascades and cellular differentiation programs. PheGe provides static and dynamic views on the establishment and maintenance of functional units of an organism and targets the construction of a virtual organism by linking intricate systems of cellular communication to an overall response. Hereby, an implemented virtual cell studio serves as a building block for the establishment of a virtual organism where regulatory, metabolic and neuronal circuits can be analyzed and artificially induced knockouts or malfunctions can be simulated on a cellular and systemic level.
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Seidl, K. (2003). Approaching Virtual Organism by PheGe. In: Banzhaf, W., Ziegler, J., Christaller, T., Dittrich, P., Kim, J.T. (eds) Advances in Artificial Life. ECAL 2003. Lecture Notes in Computer Science(), vol 2801. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-39432-7_75
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DOI: https://doi.org/10.1007/978-3-540-39432-7_75
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