Abstract
In the paper, the problem of genome mapping is considered. In particular, the restriction site approach is used for this purpose. A new, efficient algorithm for solving the Simplified Partial Digest Problem is presented. The ideal data as well as data with measurement errors can be handled by this algorithm. An extensive computational experiment proved a clear superiority of the presented algorithm over other existing approaches. In addition, a thorough analysis of the Simplified Partial Digest Problem and a discussion of common experimental errors are given.
The research has been partially supported by a KBN grant.
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References
Alizadeh, F., Karp, R.M., Weisser, D.K., Zweig, G.: Physical mapping of chromosomes using unique end-probes. Journal of Computational Biology 2, 159–184 (1995)
Bellon, B.: Construction of restriction maps. Comput. Appl. Biol. Sci. 4, 111–115 (1988)
Błażewicz, J., Formanowicz, P., Jaroszewski, M., Kasprzak, M., Markiewicz, W.T.: Construction of DNA restriction maps based on a simplified experiment. Bioinformatics 5, 398–404 (2001)
Chang, W.I., Marr, T.: Personal communication to S. Skiena (1992)
Cieliebak, M., Eidenbenz, S., Penna, P.: Noisy Data Make the Partial Digest Problem NP-hard. Technical Report 381, ETH Zurich, Department of Computer Science (2002)
Dix, T.I., Kieronska, D.H.: Errors between sites in restriction site mapping. Comput. Appl. Biol. Sci. 4, 117–123 (1988)
Goldstein, L., Waterman, M.S.: Mapping DNA by stochastic relaxation. Adv. Appl. Math. 8, 194–207 (1987)
Grigorjev, A.V., Mironov, A.A.: Mapping DNA by stochastic relaxation: a new approach to fragment sizes. Comput. Appl. Biol. Sci. 6, 107–111 (1990)
Pevzner, P.A.: Physical mapping and alternating eulerian cycles in colored graphs. Algorithmica 13, 77–105 (1995)
Rosenblatt, J., Seymour, P.: The structure of homeometric sets. SIAM J. Alg. Disc. Math. 3, 343–350 (1982)
Schmitt, W., Waterman, M.S.: Multiple solutions of DNA restriction mapping problem. Adv. Appl. Math. 12, 412–427 (1991)
Setubal, J., Meidanis, J.: Introduction to Computational Biology. PWS Publishing Company, Boston (1997)
Skiena, S.S., Smith, W.D., Lemke, P.: Reconstructing sets from interpoint distances. In: Proc. Sixth ACM Symp. Computational Geometry, pp. 332–339 (1990)
Skiena, S.S., Sundaram, G.: A partial digest approach to restriction site mapping. Bulletin of Mathematical Biology 56(2), 275–294 (1994)
Waterman, M.S.: Introduction to Computational Biology. Maps, Sequences and Genomes. Chapman & Hall, London (1995)
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Błażewicz, J., Jaroszewski, M. (2003). New Algorithm for the Simplified Partial Digest Problem. In: Benson, G., Page, R.D.M. (eds) Algorithms in Bioinformatics. WABI 2003. Lecture Notes in Computer Science(), vol 2812. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-39763-2_8
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DOI: https://doi.org/10.1007/978-3-540-39763-2_8
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-20076-5
Online ISBN: 978-3-540-39763-2
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