Abstract
Atrial fibrillation (AF) induced electrical remodelling of ionic channels shortens action potential duration and reduces atrial excitability. Experimental data of AF-induced electrical remodelling (AFER) from two previous studies on human atrial myocytes were incorporated into a human atrial cell computer model to simulate their effects on atrial electrical behaviour. The dynamical behaviors of excitation scroll waves in an anatomical 3D homogenous model of human atria were studied for control and AF conditions. Under control condition, scroll waves meandered in large area and became persistent when entrapped by anatomical obstacles. In this case, a mother rotor dominated atrial excitation. Action potentials from several sites behaved as if the atrium were paced rapidly. Under AF conditions, AFER increased the stability of re-entrant scroll waves by reducing meander. Scroll wave break up leads to wavelets underpinning sustained chronic AF. Our simulation results support the hypothesis that AF-induced electrical remodelling perpetuates and sustains AF.
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References
Lip, G.Y.: Tello-Montoliu H. Management of atrial fibrillation. Heart. 92, 1177–1182 (2006)
Bosch, R.F., Zeng, X., Grammer, J.B., Popovic, C.M., Kuhlkamp, V.: Ionic mechanisms of electrical remodeling in human atrial fibrillation. Cardiovascular Res. 44, 121–131 (1999)
Workmanm, A.J., Kane, K.A., Rankin, A.C.: The contribution of ionic currents to changes in refractoriness of human atrial myocytes associated with chronic atrial fibrillation. Cardiovascular Res. 52, 226–235 (2001)
Jongsma, H.J., Wilders, R.: Gap junctions in cardiovascular disease. Circ. Res. 86, 1193–1197 (2000)
Rostock, T., O’Neill, M.D., Takahashi, Y., Sanders, P., Haissaguerre, M.: Interactions between two simultaneous tachycardias within electrically isolated pulmonary veins. J. Cardiovsac. Electrophysiol. 18, 441–445 (2007)
Huang, C.X., Hu, C.L., Li, Y.B.: Atrial fibrillation may be a vascular disease: The role of pulmonary veins. Med. Hypotheses 68(3), 629–634 (2007)
Kamanu, S., Tan, A.Y., Peter, C.T., Hwang, C., Chen, P.S.: Vein of Marshall activity during sustained atrial fibrillation. J. Cardiovasc. Electrophysiol. 17(8), 839–846 (2006)
Nattel, S., Carlsson, L.: Innovative approach to anti-arrhythmic drug therapy. Nat. Rev. Drug Discov. 5(12), 1034–1049 (2006)
Hersi, A., Wyse, D.G.: Medical management of atrial fibrillation. Curr. Cardiol. Rep. 8(5), 323–329 (2006)
Verdino, R.J.: The evolution of atrial fibrillation ablation from triggers to substrate. J. Electrocardiol. 39(4), S184–S187 (2006)
Purerfellner, H., Aichinger, J., Martinek, M., Nesser, H., Janssen, J.: Short- and long-term experience in pulmonary vein segmental ostial ablation for paroxysmal atrial fibrillation. Indian Pacing Electrophysiol. J. 6(1), 6–16 (2006)
Lazar, S., Dixit, S., Callans, D.J., Lin, D., Marchlinski, F.E., Gerstenfeld, E.P.: Effect of pulmonary vein isolation on the left-to-right atrial dominant frequency gradient in human atrial fibrillation. 3(8), 889–895 (2006)
Sulke, N., Sayers, F., Lip, G.Y.: Rhythm control and cardioversion. Heart 93(1), 29–34 (2007)
Courtemanche, M., Ramirez, R.J., Nattel, S.: Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model. Am. J. Physiol. 275, H301–H321 (1998)
Seemann, G., Hoper, C., Sachse, F.B., Dossel, O., Holden, A.V., Zhang, H.: Heterogeneous three-dimensional anatomical and electrophysiological model of human atria. Phil. Trans. A. 364, 1465–1481 (2006)
Biktasheva, I.V., Biktashev, V.N., Holden, A.V.: Self-termination of spiral waves in a model of human atrial tissue. In: Frangi, A.F., Radeva, P.I., Santos, A., Hernandez, M. (eds.) FIMH 2005. LNCS, vol. 3504, pp. 293–303. Springer, Heidelberg (2005)
Hanson, C., Jonson, Ch.: The visualization handbook. Elsevier, Butterworth-Heinemann (2005)
Byung-Soo, K., Young-Hoon, K., Gyo-Seung, H., Hui-Nam, P., Sang Chil, L., Wan Joo, S., Dong Joo, O., Young Moo, R.: Action potential duration restitution kinetics in human atrial fibrillation. J. Am. Col. Cardiol. 39(8), 1329–1336 (2002)
Xie, F., Qu, Z., Garfinkel, A., Weiss, J.: Electrical refractory period restitution and spiral wave reentry in simulated cardiac tissue. Am. J. Physiol. Heart Circ. Physiol. 283, 448–460 (2002)
Zhang, H., Garratt, C.J., Zhu, J., Holden, A.V.: Role of up-regulation of IK1 in action potential shortening associated with atrial fibrillation in humans. Cardiovasc Res. 66, 493–502 (2005)
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Kharche, S., Seemann, G., Leng, J., Holden, A.V., Garratt, C.J., Zhang, H. (2007). Scroll Waves in 3D Virtual Human Atria: A Computational Study. In: Sachse, F.B., Seemann, G. (eds) Functional Imaging and Modeling of the Heart. FIMH 2007. Lecture Notes in Computer Science, vol 4466. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-72907-5_14
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DOI: https://doi.org/10.1007/978-3-540-72907-5_14
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