Abstract
The purpose of this study is to introduce unique experimental measurements of extracellular potentials mapped from the epicardial surface of mouse hearts that reflect the same structural features seen in larger mammalian hearts. The measurements obtained in this study provide an important tool for studying the impacts of structural changes on propagation in genetically modified mouse models of cardiac disease. Unipolar electrograms were recorded using a high-resolution electrode array to map the epicardial surface of mouse hearts during atrial drive and at increasing transmural pacing depths. The extracellular potential maps revealed the underlying fiber structure of the mouse heart that is shown to be similar to those previously published from other species. This imaging technique, when integrated with computer models and diffusion tensor imaging can substantially contribute to our understanding of innovative genetic mouse models being used in the study of human cardiac disease.
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Sutherland, D.R., Liang, Q., Sohn, K., Taccardi, B., Punske, B.B. (2007). Experimental Epicardial Potential Mapping in Mouse Ventricles: Effects of Fiber Architecture. In: Sachse, F.B., Seemann, G. (eds) Functional Imaging and Modeling of the Heart. FIMH 2007. Lecture Notes in Computer Science, vol 4466. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-72907-5_27
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DOI: https://doi.org/10.1007/978-3-540-72907-5_27
Publisher Name: Springer, Berlin, Heidelberg
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