Abstract
Sarcoidosis is a multisystem disorder that is characterized by the formation of granulomas in certain organs of the body. The exact cause of sarcoidosis is unknown but evidence exists that sarcoidosis results from exposure of genetically susceptible hosts to specific environmental agents. The wide degree of clinical heterogeneity might indicate that sarcoidosis is not a single polymorphic disease but a collection of genetically complex diseases. As a first step to identify the hypothesized subcategories, large amounts of multidimensional data are collected that are divided into distinct levels. We investigated how clustering techniques can be applied to support the interpretation of sarcoidosis and subsequently to reveal categories of sarcoidosis data. An attempt is made to relate multiple clusters between the different data levels based on validation criteria.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Demedts, M., Wells, A.U., Anto, J.M., Costabel, U., Hubbard, R., Cullinan, P., Slabbynck, H., Rizzato, G., Poletti, V., Verbeken, E.K., Thomeer, M.J., Kokkarinen, J., Dalphin, J.C., Taylor, A.N.: Interstitial lung diseases: an epidemiological overview. Respir J Suppl. 32, 2–16 (2001)
Newman, L.S., Rose, C.S., Maier, L.A.: Sarcoidosis. N Engl. J Med. 336, 1224–1234 (1997)
Gower, J.C.: A general coefficient of similarity and some of its properties. Biometrics 23, 623–628 (1971)
Estivill-Castro, V.: Why so many clustering algorithms: A position paper. SIGKDD Explorations 4, 65–75 (2002)
Jain, A.K., Murty, M.N., Flynn, P.J.: Data clustering: A review. ACM Computing Surveys 31, 264–323 (1999)
Duda, R.O., Hart, P.E., Stork, D.G.: Pattern Classification, 2nd edn. Wiley-Interscience, New York (2000)
Kaufman, L., Rousseeuw, P.J.: Finding Groups in Data: An Introduction to Cluster Analysis. Wiley-Interscience, New York (1990)
Handl, J., Knowles, J., Kell, D.B.: Computational cluster validation in post-genomic data analysis. Bioinformatics 21, 3201–3212 (2005)
Halkidi, M., Batistakis, Y., Vazirgiannis, M.: On clustering validation techniques. Journal of Intelligent Information Systems 17, 107–145 (2001)
Rousseeuw, P.J.: Silhouettes: a graphical aid to the interpretation and validation of cluster analysis. Journal of Computational and Applied Mathematics 20, 53–65 (1987)
Dunn, J.: Well separated clusters and optimal fuzzy partitions. J. Cybernetics 4, 95–104 (1974)
Hubert, L., Arabie, P.: Comparing partitions. Journal of Classification 2, 193–218 (1985)
Steinley, D.: Properties of the Hubert-Arabie Adjusted Rand Index. Psychological Methods 9, 386–396 (2004)
Author information
Authors and Affiliations
Editor information
Rights and permissions
Copyright information
© 2007 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Karthaus, V.L.J., Donkers, H.H.L.M., Grutters, J.C., van den Herik, H.J., van den Bosch, J.M.M. (2007). Multi-level Clustering in Sarcoidosis: A Preliminary Study. In: Bellazzi, R., Abu-Hanna, A., Hunter, J. (eds) Artificial Intelligence in Medicine. AIME 2007. Lecture Notes in Computer Science(), vol 4594. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-73599-1_27
Download citation
DOI: https://doi.org/10.1007/978-3-540-73599-1_27
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-73598-4
Online ISBN: 978-3-540-73599-1
eBook Packages: Computer ScienceComputer Science (R0)