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International Conference on Artificial Immune Systems

ICARIS 2008: Artificial Immune Systems pp 364–375Cite as

The Pathways of Complement

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Part of the book series: Lecture Notes in Computer Science ((LNTCS,volume 5132))

Abstract

The natural world has developed very effective methods for dealing with pathogens that are invading an organism. By taking inspiration from the in-built, innate, response this paper develops a new algorithm that mimics activation path of the Alternative Pathway of Complement. The Alternative Pathway is triggered by cell surfaces. If the surfaces display safe characteristics then a strong suppression process prevents activation. In the case of non-safe surfaces a positive feedback loop rapidly identifies the location marking it for removal by phagocytosis.

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References

  1. Schaust, S., Szczerbicka, H.: Artificial immune systems in the context of misbehavior detection. Cybernetics and Systems 39(2), 136–154 (2008)

    Article  Google Scholar 

  2. Wittig, T., Jennings, N.R., Mamdani, E.H.: ARCHON - A framework for intelligent cooperation. IEE-BCS Journal of Intelligent Systems Engineering - Special Issue on Real-time Intelligent Systems in ESPRIT 3(3), 168–179 (1994)

    Google Scholar 

  3. Festinger, L.: A theory of social comparison processes. Human Relations 7, 117–140 (1954)

    Article  Google Scholar 

  4. Kaminka, G.A., Tambe, M.: Social comparison for failure detection and recovery. In: Agent Theories, Architectures, and Languages, pp. 127–141 (1997)

    Google Scholar 

  5. Kaminka, G.A., Pynadath, D.V., Tambe, M.: The role of agent-modeling in agent robustness. In: Proceedings of the conference on AI meets the real-world (1998)

    Google Scholar 

  6. Kaminka, G.A., Tambe, M.: What is wrong with us? improving robustness though social diagnosis. In: Proceedings of the Fifteenth National Conference on Artificial Conference on Artificial Intelligence AAAI 1998 Tenth Conference on Innovative Applications of Artificial Intelligence, pp. 97–104 (1998)

    Google Scholar 

  7. Thurman, J.M., Holers, V.M.: The central role of the alternative complement pathway in human disease. Journal of Immunology 176, 1305–1310 (2006)

    Google Scholar 

  8. Köhl, J.: The role of complement in danger sensing and transmission. Immunologic Research 34(2), 157–176 (2006)

    Article  Google Scholar 

  9. Köhl, J.: Self, non-self and danger: A complementary view. Advances in Experimental Medicine and Biology 586, 71–94 (2006)

    Article  Google Scholar 

  10. Thielens, N.M., Tacnet-Delorme, P., Arlaud, G.J.: Interaction of c1q and mannan-binding lectin with viruses. Immunobiology 205, 563–574 (2002)

    Article  Google Scholar 

  11. Kerr, M.A.: The human complement system: Assembly of the classical pathway c3 convertase. The Biochemical Journal 189, 173–181 (1980)

    Google Scholar 

  12. Janeway, C., Travers, P., Walport, M., Schlomchik, M.: Immunobiology - The Immune System in Health and Disease, 6th edn. Garland Science Publishing (2005)

    Google Scholar 

  13. Degn, S.E., Thiel, S., Jensenius, J.C.: New perspectives on mannan-binding lectin-mediated complement activation. Immunobiology 212, 301–311 (2007)

    Article  Google Scholar 

  14. Endo, Y., Takahashi, M., Fujita, T.: Lectin complement system and pattern recognition. Immunobiology 211, 283–293 (2006)

    Article  Google Scholar 

  15. Wallis, R.: Structural and functional aspects of complement activation by mannose-binding protein. Immunobiology 205, 433–445 (2002)

    Article  Google Scholar 

  16. Hajela, K., Kojima, M., Ambrus, G., Wong, K.H.N., Moffatt, B.E., Ferluga, J., Hajela, S., Gál, P., Sim, R.B.: The biological functions of MB-associated serine proteases (MASPs). Immunobiology 205, 467–475 (2002)

    Article  Google Scholar 

  17. Wallis, R.: Interactions between mannose-binding lectin and MASPs during complement activation by the lectin pathway. Immunobiology 212, 289–299 (2007)

    Article  Google Scholar 

  18. Walport, M.J.: Complement - first of two parts. New England Journal of Medicine 344(14), 1058–1066 (2001)

    Article  Google Scholar 

  19. Pangburn, M.K., Müller-Eberhard, H.J.: The alternative pathway of complement. Springer Seminars in Immunopathology 7, 163–192 (1984)

    Article  Google Scholar 

  20. Nicol, P.A.E., Lachmann, P.J.: The alternative pathway of complement activation. The role of C3 and its inactivator (KAF). Immunology 24, 259–265 (1973)

    Google Scholar 

  21. Müller-Eberhard, H.J.: Molecular organization and function of the complement system. Annual Reviews of Biochemistry 57, 321–347 (1988)

    Article  Google Scholar 

  22. Whaley, K., Ruddy, S.: Modulation of the alternative complement pathway by β1H globulin. Journal of Experimental Medicine 144, 1147–1163 (1976)

    Article  Google Scholar 

  23. Weiler, J.H., Daha, M.R., Austen, K.F., Fearon, D.T.: Control of the amplification convertase of complement by the plasma protein β1H. Proceedings of the National Academy of Science USA 73(9), 3268–3272 (1976)

    Article  Google Scholar 

  24. Pangburn, M.K., Müller-Eberhard, H.J.: Complement c3 convertase: Cell surface restriction of β1H control and generation of restriction on neuraminidase-treated cells. Proceedings of the National Academy of Science USA 75(5), 2416–2420 (1978)

    Article  Google Scholar 

  25. Kazatchkine, M.D., Fearon, D.T., Austen, K.F.: Human alternative complement pathway: Membrane associated sialic acid regulates the competition between B and β1H for cell-bound C3b. Journal of Immunology 122(1), 75–81 (1979)

    Google Scholar 

  26. Hourcade, D.E.: The role of properdin in the assembly of the alternative pathway c3 convertases of complement. The Journal of Biological Chemistry 281, 2128–2132 (2006)

    Article  Google Scholar 

  27. Zipfel, P.F., Mihlan, M., Skerka, C.: The alternative pathway of complement: A pattern recognition system. Advances in Experimental Medicine and Biology 598, 80–92 (2007)

    Article  Google Scholar 

  28. Nilsson, U.R., Müller-Eberhard, H.J.M.: Isolation of β 1F -globulin from human serum and its characterization as the fifth component of complement. Journal of Experimental Medicine 122, 277–298 (1965)

    Article  Google Scholar 

  29. de Córdoba, S.R., Esparza-Gordillo, J., de Jorge, E.G., Lopez-Trascasa, M., Sánchez-Corral, P.: The human complement factor H: Functional roles, genetic variations and disease associations. Molecular Immunobiology 41, 355–367 (2004)

    Google Scholar 

  30. Alexander, J.J., Quigg, R.J.: The simple design of complement factor H: Looks can be deceiving. Molecular Immunology 44, 123–132 (2007)

    Article  Google Scholar 

  31. Fearon, D.T.: Regulation by membrane sialic acid of β1H-dependent decay-dissociation of amplification C3 converase of the alternate complement pathway. Proceedings of the National Academy of Science USA 75, 1971–1975 (1978)

    Article  Google Scholar 

  32. Meri, S., Pangburn, M.K.: Discrimination between activators and nonactivators of the alternative pathway of complement: Regulation via a sialic acid polyanion binding site on factor h. In: Proceedings of the National Academy of Sciences of the United States of America, vol. 87, pp. 3982–3986 (1990)

    Google Scholar 

  33. Pangburn, M.K., Schreiber, R.D., Trombold, J.S., Müller-Eberhard, H.J.: Paroxysmal nocturnal hemoglobinuria: Deficiency in factor h-like functions of the abnormal erythrocytes. Journal of Experimental Medicine 157, 1971–1980 (1983)

    Article  Google Scholar 

  34. Favoreel, H.W., de Walle, G.R.V., Nauwynck, H.J., Pensaert, M.B.: Virus complement evasion strategies. Journal of General Virology 84, 1–15 (2003)

    Article  Google Scholar 

  35. Pangburn, M.K.: Host recognition and target differentiation by factor H, a regulator of the alternative pathway of complement. Immunopharmacology 49, 149–157 (2000)

    Article  Google Scholar 

  36. Pangburn, M.K., Pangburn, K.L.W., Koistinen, V., Meri, S., Sharma, A.K.: Molecular mechanisms of target recognition in an innate immune system: Interactions among factor H, C3b and target in the alternative pathway of human complement. The Journal of Immunology 164, 4742–4751 (2000)

    Google Scholar 

  37. Bellifemine, F., Poggi, A., Rimassa, G.: JADE - a FIPA-compliant agent framework. In: Proceedings of Practical Application of Intelligent Agents and MultiAgents (PAAM 1999), pp. 97–108 (1999)

    Google Scholar 

  38. Kreyszig, E.: Advanced Engineering Mathematics. John Wiley & Sons Inc., Chichester (1999)

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Electronics, University of York, Heslington, York, YO10 5DD, UK

    Jonathan M. Aitken, Tim Clarke & Jonathan I. Timmis

Authors
  1. Jonathan M. Aitken
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  2. Tim Clarke
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  3. Jonathan I. Timmis
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Editor information

Peter J. Bentley Doheon Lee Sungwon Jung

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© 2008 Springer-Verlag Berlin Heidelberg

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Aitken, J.M., Clarke, T., Timmis, J.I. (2008). The Pathways of Complement. In: Bentley, P.J., Lee, D., Jung, S. (eds) Artificial Immune Systems. ICARIS 2008. Lecture Notes in Computer Science, vol 5132. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-85072-4_32

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  • DOI: https://doi.org/10.1007/978-3-540-85072-4_32

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-85071-7

  • Online ISBN: 978-3-540-85072-4

  • eBook Packages: Computer ScienceComputer Science (R0)

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