Abstract
Gene expression is the process of decoding the information in a DNA sequence into a protein. In this process, an enzyme called RNA-polymerase transcribes DNA into messenger-RNA, which is translated into protein. The determinant factors to decide which protein belongs to each cell and how much of it will be produced are the concentration of mRNA, and the frequency mRNA is translated. Operators and regulators, called transcription factors, control the transcription process. The gene regulation network consists of determining how and which transcription factors are positioned in some DNA sequence. In this work, we explore the ability of genetic algorithms to search in complex spaces to find predictions of possible units of genetic information. We propose four approaches to solve this problem, trying to identify the pertinent set of parameters to be used. We use E. coli sigma 70 promoters as a study of case.
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Wanderley, M.F.B., da Silva, J.C.P., Borges, C.C.H., Vasconcelos, A.T.R. (2008). Application of Genetic Algorithms to the Genetic Regulation Problem. In: Bazzan, A.L.C., Craven, M., Martins, N.F. (eds) Advances in Bioinformatics and Computational Biology. BSB 2008. Lecture Notes in Computer Science(), vol 5167. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-85557-6_13
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DOI: https://doi.org/10.1007/978-3-540-85557-6_13
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