Abstract
Each post-translational modification (PTM) of proteins only modifies one or several limited types of amino acids to ensure regulatory fidelity. Thus proteins without one or several types of amino acids (amino acid absence, AAA) might prohibit some PTMs. We performed a proteome-wide analysis to compute AAA proteins in six eukaryotic organisms. Although most of AAA proteins are generated by random during evolution, there are 1,220 (~10%) AAA proteins conserved in human and mouse, implying the amino acid absence might be important for a small proportion of proteins as an evolutionary mechanism. In addition, five of 25 K-deficient proteins are static keratin-associated proteins, which interact with keratins and play important roles in animal hair organization.
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Zhao, Y. et al. (2008). Proteome-Wide Analysis of Amino Acid Absence in Composition and Plasticity. In: Huang, DS., Wunsch, D.C., Levine, D.S., Jo, KH. (eds) Advanced Intelligent Computing Theories and Applications. With Aspects of Theoretical and Methodological Issues. ICIC 2008. Lecture Notes in Computer Science, vol 5226. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-87442-3_22
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DOI: https://doi.org/10.1007/978-3-540-87442-3_22
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