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International School on Neural Networks, Initiated by IIASS and EMFCSC

NN 2007: Dynamic Brain - from Neural Spikes to Behaviors pp 28–37Cite as

Mechanisms for Memory-Guided Behavior Involving Persistent Firing and Theta Rhythm Oscillations in the Entorhinal Cortex

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Part of the book series: Lecture Notes in Computer Science ((LNTCS,volume 5286))

Abstract

Interactions of hippocampal and parahippocampal regions are important for memory-guided behavior. Understanding the role of these structures requires understanding the interaction of populations of neurons, including the cellular properties of neurons in structures such as the entorhinal cortex. Recent data and modeling suggest an important role for cellular mechanisms of persistent spiking and membrane potential oscillations in medial entorhinal cortex, both in mechanisms for spatial navigation and for episodic memory function. Both persistent firing and membrane potential oscillations may provide mechanisms for path integration at a cellular level based on speed-modulated head direction as a velocity signal. This path integration process thereby provides a potential mechanism for grid cell firing properties in medial entorhinal cortex. Incorporation of these processes into a larger scale model allows simulation of mechanisms for sequence encoding and episodic memory.

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Authors and Affiliations

  1. Center for Memory and Brain and Program in Neuroscience, Boston University, 2 Cummington St., Boston, Massachusetts, 02215

    Michael E. Hasselmo, Lisa M. Giocomo, Mark P. Brandon & Motoharu Yoshida

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  1. Michael E. Hasselmo
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  2. Lisa M. Giocomo
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  3. Mark P. Brandon
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  4. Motoharu Yoshida
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Editors and Affiliations

  1. Dipartimento di Fisica “E.R. Caianiello”, Università degli Studi di Salerno, Via S. Allende, 84081, Baronissi (SA), Italy

    Maria Marinaro  & Silvia Scarpetta  & 

  2. Laboratory for Dynamics of Emergent Intelligence, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako-shi, 351-0198, Saitama, Japan

    Yoko Yamaguchi

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Hasselmo, M.E., Giocomo, L.M., Brandon, M.P., Yoshida, M. (2008). Mechanisms for Memory-Guided Behavior Involving Persistent Firing and Theta Rhythm Oscillations in the Entorhinal Cortex. In: Marinaro, M., Scarpetta, S., Yamaguchi, Y. (eds) Dynamic Brain - from Neural Spikes to Behaviors. NN 2007. Lecture Notes in Computer Science, vol 5286. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-88853-6_3

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  • DOI: https://doi.org/10.1007/978-3-540-88853-6_3

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