Abstract
The paper deals with in silico investigation of possible regulatory mechanisms involved in control of signaling pathways. As an example, the Interferon- b activated pathway has been chosen. Though many processes involved in this pathway are known, there are still some that evade explanation. One of them is the nuclear accumulation of the IRF1 protein. Here, three hypotheses are stated and tested numerically, showing that the most likely mechanism involved in this process is an inhibition of IRF1 activation by an yet unrecognized factor.
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Smieja, J. (2009). Simulation Methods in Uncovering New Regulatory Mechanisms in Signaling Pathways. In: Rajasekaran, S. (eds) Bioinformatics and Computational Biology. BICoB 2009. Lecture Notes in Computer Science(), vol 5462. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-00727-9_37
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DOI: https://doi.org/10.1007/978-3-642-00727-9_37
Publisher Name: Springer, Berlin, Heidelberg
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