Abstract
We have investigated different mathematical models for signaling pathways and built a new pathway model for TNFα-NFκB signaling using an integrative analytical approach. This integrative approach consists of a knowledgebase, model designing/visualization and simulation environments. In particular, our new TNFα-NFκB signaling pathway model was developed based on literature studies and the use of ordinary differential equations and a detailed protein-protein interaction connectivity map within this approach. Using the most detailed mathematical model as a base model, three new relevant proteins – TRAF1, FLIP, and MEKK3 – were identified and included in our new model. Our results show that this integrative approach offers the most detailed and consistent mathematical description for TNFα-NFκB signaling and further increases the understanding of TNFα-NFκB signaling pathway.
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Visvanathan, M., Pfeifer, B., Baumgartner, C., Tilg, B., Lushington, G.H. (2009). Integrative Approach for Combining TNFα-NFκB Mathematical Model to a Protein Interaction Connectivity Map. In: Măndoiu, I., Narasimhan, G., Zhang, Y. (eds) Bioinformatics Research and Applications. ISBRA 2009. Lecture Notes in Computer Science(), vol 5542. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-01551-9_7
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DOI: https://doi.org/10.1007/978-3-642-01551-9_7
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