Abstract
Experimentally observed differences in the action potential (AP) properties – primarily, refractoriness – between the left (LA) and right (RA) atria are believed to be important in maintaining atrial fibrillation. We incorporate AP models for single LA and RA cells into 2D atrial tissue models and study the role of tissue heterogeneity in global interaction between reentrant spiral waves in the LA and RA. Our simulations show that shorter refractoriness in the LA translates into a shorter period of spiral rotation, and as a result, reentry in the LA dominates the overall excitation patterns in the atria.
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Aslanidi, O.V., Boyett, M.R., Zhang, H. (2009). Left to Right Atrial Electrophysiological Differences: Substrate for a Dominant Reentrant Source during Atrial Fibrillation. In: Ayache, N., Delingette, H., Sermesant, M. (eds) Functional Imaging and Modeling of the Heart. FIMH 2009. Lecture Notes in Computer Science, vol 5528. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-01932-6_17
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DOI: https://doi.org/10.1007/978-3-642-01932-6_17
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-01931-9
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