Abstract
PathJam is a new comprehensive and freely accessible web-server application integrating scattered human pathway annotation from several public sources. The tool has been designed to be intuitive for wet-lab users providing statistical enrichment analysis of pathway annotation for a given gene list of interest. Results are displayed in several interactive and downloadable views (graphs, spread-sheets, etc.) facilitating the biological interpretation of the gene lists. Moreover, PathJam allows users to build their own gene sets files in order to use them in gene set enrichment-based analysis. Finally, a simplified version of PathJam has been also implemented as a widget and is currently available for CARGO users.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Dennis Jr., G., Sherman, B.T., Hosack, D.A., Yang, J., Gao, W., Lane, H.C., Lempicki, R.A.: DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biology 4(5), P3 (2003)
Al-Shahrour, F., Minguez, P., Tárraga, J., Medina, I., Alloza, E., Montaner, D., Dopazo, J.: FatiGO +: a functional profiling tool for genomic data. Integration of functional annotation, regulatory motifs and interaction data with microarray experiments. Nucleic Acids Res. 35(web server issue), W91–W96 (2007)
Cases, I., Pisano, D.G., Andres, E.l., Carro, A., Fernández, J.M., Gómez-López, G., Rodriguez, J.M., Vera, J.F., Valencia, A., Rojas, A.M.: CARGO: a web portal to integrate customized biological information. Nucleic Acids Res. 35(web server issue), W16–W20 (2007)
Subramaniana, A., Tamayoa, P., Mootha, V.K., Mukherjee, S., Ebert, B.L., Gillette, M.A., Paulovich, A., Pomeroy, S.L., Golub, T.R., Lander, E.S., Mesirov, J.P.: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc. Nat. Acad. Sci. 102(43), 15545–15550 (2005)
Vastrik, I., D’Eustachio, P., Schmidt, E., Joshi-Tope, G., Gopinath, G., Croft, D., de Bono, B., Gillespie, M., Jassal, B., Lewis, S., Matthews, L., Wu, G., Birney, E., Stein, L.: Reactome: a knowledge base of biologic pathways and processes. Genome Biology 8, R39 (2007)
Kanehisa, M., Araki, M., Goto, S., Hattori, M., Hirakawa, M., Itoh, M., Katayama, T., Kawashima, S., Okuda, S., Tokimatsu, T., Yamanishi, Y.: KEGG for linking genomes to life and the environment. Nucleic Acids Res. 36(database issue), D480–D484 (2008)
Krupa, S., Anthony, K., Buchoff, J.R., Day, M., Hannay, T., Schaefer, C.F.: The NCI-Nature Pathway Interaction Database: A cell signaling resource. NCI-Nature Pathway Interaction Database 446, 153–158 (2007)
Biocarta. Charting Pathways of Life (2008), http://www.biocarta.com
Benjamini, Y., Hochberg, Y.: Controlling the false discovery rate: a practical and powerful approach to multiple testing. Journal of the Royal Statistical Society. Series B (Methodological) 57(1), 289–300 (1995)
Tracey, L., Aggarwal, M., García-Cosio, M., Villuendas, R., Algara, P., Sánchez-Beato, M., Sánchez-Aguilera, A., García, J.F., Rodríguez, A., Camacho, F.I., Martínez, N., Ruiz-Ballesteros, E., Mollejo, M., Piris, M.A.: Somatic hypermutation signature in B-cell low-grade lymphomas. Haematol. 93(8), 1186–1194 (2008)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Glez-Peña, D., Domínguez, R., Gómez-López, G., Pisano, D.G., Fdez-Riverola, F. (2009). Current Efforts to Integrate Biological Pathway Information. In: Omatu, S., et al. Distributed Computing, Artificial Intelligence, Bioinformatics, Soft Computing, and Ambient Assisted Living. IWANN 2009. Lecture Notes in Computer Science, vol 5518. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02481-8_165
Download citation
DOI: https://doi.org/10.1007/978-3-642-02481-8_165
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-02480-1
Online ISBN: 978-3-642-02481-8
eBook Packages: Computer ScienceComputer Science (R0)