Abstract
This paper investigates the dynamics of cell migration, which is the movement of a cell towards a certain target area. More specifically, the objective is to analyze the causal interdependence between cellular-morphological events and molecular-signaling events. To this end, a novel data analysis method is developed: first the local morphological changes and molecular signaling events are determined by means of edge evolution tracking (EET), next the interdependence of those events is quantified through the method of stochastic event synchrony (SES).
The proposed method is applied to time-lapse fluorescence resonance energy transfer (FRET) images of Rac1 activity in motile HT1080 cells; the protein Rac1 is well known to induce filamentous structures that enable cells to migrate. Results show a significant delay between local Rac1 activity events and morphological events. This observation provides new insights into the dynamic relationship between cellular-morphological change and molecular-signaling of migrating cells, and may pave the way to novel biophysical models of cell migration.
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Dauwels, J. et al. (2009). On the Synchrony of Morphological and Molecular Signaling Events in Cell Migration. In: Köppen, M., Kasabov, N., Coghill, G. (eds) Advances in Neuro-Information Processing. ICONIP 2008. Lecture Notes in Computer Science, vol 5506. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02490-0_58
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DOI: https://doi.org/10.1007/978-3-642-02490-0_58
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-02489-4
Online ISBN: 978-3-642-02490-0
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