Abstract
Disruption of the mechanisms that regulate cell-cycle checkpoints, DNA repair, and apoptosis results in genomic instability and the development of cancer. The description of the complex network of these pathways requires news tools to integrate large quantities of experimental data in the design of biological information systems. In this context we present Ontocancro an extensible ontology and an architecture designed to facilitate the integration of data originating from different public databases in a single- and well-documented relational database. Ontocancro is an Ontology stored in a knowledge database designed to be a source of information to integrate transcriptomics and interatomics data involved in gene pathways of Genome Maintenance Mechanisms (GMM).
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References
Bradley, N.: The XML Companion, 3rd edn. Addison-Wesley, Reading (2002)
Castro, M.A.A., Dalmolin, R.L.S., Moreira, J.C.F., Mombach, J.C.M., de Almeida, R.M.C.: Evolutionary origins of human apoptosis and genome-stability gene networks. Nucleic Acids Res. 36(19), 6269–6283 (2008)
Castro, M.A.A., Mombach, J.C.M., de Almeida, R.M.C., Moreira, J.C.F.: Impaired expression of ner gene network in sporadic solid tumors. Nucleic Acids Res. 35(6), 1859–1867 (2007)
Guarino, N.: Formal Ontology and Information Systems. In: Conference on Formal Ontology (FOIS 1998) (1998)
Librelotto, G.R., Ramalho, J.C., Henriques, P.R., Gassen, J.B., Turchetti, R.C.: A framework to specify, extract and manage Topic Maps driven by ontology. In: SIGDOC 2008. ACM Press, New York (2008)
Park, J., Hunting, S.: XML Topic Maps: Creating and Using Topic Maps for the Web. Addison-Wesley, Reading (2003)
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Librelotto, G.R., Mombach, J.C., Sinigaglia, M., Simão, É., Cabral, H.B., Castro, M.A.A. (2009). An Ontology to Integrate Transcriptomics and Interatomics Data Involved in Gene Pathways of Genome Stability. In: Guimarães, K.S., Panchenko, A., Przytycka, T.M. (eds) Advances in Bioinformatics and Computational Biology. BSB 2009. Lecture Notes in Computer Science(), vol 5676. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-03223-3_18
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DOI: https://doi.org/10.1007/978-3-642-03223-3_18
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-03222-6
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