Abstract
The cellular frustration concept was first introduced in an ICARIS conference [1] as an alternative approach to accomplish specific and prompt intrusion detection in highly diverse systems. Cellular frustration uses two main assumptions: 1) that cells’ activation are better modeled as cellular decisions and 2) that these cells’ decisions require a finite amount of time to be triggered. These two assumptions have been gaining experimental support. It is now well established that T cells activation requires a considerable amount of time [2]. Experimental observations also suggest that interactions of T cells with APCs could be better modeled as cellular decisions rather than conventional probabilistic reactions [3],[4]. As a result from these assumptions the cellular frustration framework (CFF) is capable of reconciling two apparently opposing phenomena, namely high reactivity against nonself with total tolerance towards self [4].
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References
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de Abreu, F.V., Mostardinha, P. (2009). Nonself Detection in a Two-Component Cellular Frustrated System. In: Andrews, P.S., et al. Artificial Immune Systems. ICARIS 2009. Lecture Notes in Computer Science, vol 5666. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-03246-2_6
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DOI: https://doi.org/10.1007/978-3-642-03246-2_6
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