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On Coupling Models Using Model-Checking: Effects of Irinotecan Injections on the Mammalian Cell Cycle

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Computational Methods in Systems Biology (CMSB 2009)

Part of the book series: Lecture Notes in Computer Science ((LNBI,volume 5688))

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Abstract

In systems biology, the number of models of cellular processes increases rapidly, but re-using models in different contexts or for different questions remains a challenging issue. In this paper, we show how the validation of a coupled model and the optimization of its parameters with respect to biological properties formalized in temporal logics, can be done automatically by model-checking. More specifically, we illustrate this approach with the coupling of existing models of the mammalian cell cycle, the p53-based DNA-damage repair network, and irinotecan metabolism, with respect to the biological properties of this anticancer drug.

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Author information

Authors and Affiliations

  1. Project-team Contraintes, INRIA Paris-Rocquencourt, France

    Elisabetta De Maria, François Fages & Sylvain Soliman

Authors
  1. Elisabetta De Maria
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  2. François Fages
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  3. Sylvain Soliman
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Editor information

Editors and Affiliations

  1. Dipartimento di Informatica, Università di Pisa, Largo Bruno Pontecorvo, 3, 56127, Pisa, Italy

    Pierpaolo Degano

  2. Dipartimento di Scienze dell’Informazione, Università degli Studi di Bologna, Mura Anteo Zamboni 7, 40127, Bologna, Italy

    Roberto Gorrieri

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De Maria, E., Fages, F., Soliman, S. (2009). On Coupling Models Using Model-Checking: Effects of Irinotecan Injections on the Mammalian Cell Cycle. In: Degano, P., Gorrieri, R. (eds) Computational Methods in Systems Biology. CMSB 2009. Lecture Notes in Computer Science(), vol 5688. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-03845-7_10

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  • DOI: https://doi.org/10.1007/978-3-642-03845-7_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-03844-0

  • Online ISBN: 978-3-642-03845-7

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