Abstract
An improved model of action potentials (AP) is proposed to increase the accuracy of simulated electrocardiograms (ECGs). ECG simulator is based on a spatial model of a left ventricle, composed of cubic cells. Three distinct APs, modeled with functions proposed by Wohlfard, have been assigned to the cells, forming epicardial, mid, and endocardial layers. Identification of exact parameter values for AP models has been done through optimization of the simulated ECGs. Results have shown that only through an introduction of a minor extension to the AP model, simulator is able to produce more realistic ECGs. The same extension also proves essential for achieving a better fit between the measured and modeled APs.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ten Tusscher, K., Noble, D., Noble, P., Panfilov, A.: A model for human ventricular tissue. Am. J. Physiol. Heart Circ. Physiol. 286, H1573–H1589(2004)
Wohlfart, B.: A simple model for demonstration of SST-changes in ECG. Eur. Heart J. 8, 409–416 (1987)
Surawicz, B.: U wave: Facts, hypotheses, misconceptions, and misnomers. J. Cardiovasc. Electrophysiol. 9, 1117–1128 (1998)
Pérez Riera, A., Ferreira, C., Filho, C., Ferreira, M., Meneghini, A., Uchida, A., Schapachnik, E., Dubner, S.L.Z.: The enigmatic sixth wave of the electrocardiogram: the U wave. Cardiol. J. 15, 408–421 (2008)
Watanabe, Y.: Purkinje repolarization as a possible cause of the U wave in the electrocardiogram. Circulation 51, 1030–1037 (1975)
Franz, M.: Mechano-electrical feedback in ventricular myocardium. Cardiovasc Res. 32, 15–24 (1996)
Schimpf, R., Antzelevitch, C., Haghi, D., Giustetto, C., Pizzuti, A., Gaita, F., Veltmann, C., Wolpert, C., Borggrefe, M.: Electromechanical coupling in patients with the short QT syndrome: further insights into the mechanoelectrical hypothesis of the U wave. Heart Rhythm 5, 241–245 (2008)
Druin, E., Charpentier, F., Gauthier, C., Laurent, K., Le Marec, H.: Electrophysiologic characteristics of cells spanning the left ventricular wall of human heart: Evidence for presence of M cells. J. Am. Coll. Cardiol. 26, 185–192 (1995)
van Ritsema Eck, H., Kors, J., van Herpen, G.: The U wave in the electrocardiogram: A solution for a 100-year-old riddle. Cardiovasc Res. 67, 256–262 (2005)
Depolli, M., Avbelj, V., Trobec, V.: Computer-simulated alternative modes of U-wave genesis. J. Cardiovasc. Electrophysiol. 19, 84–89 (2008)
Macfarlane, P., Lawrie, T. (eds.): Comprehensive Electrocardiology: Theory and Practice in Health and Disease, 1st edn., vol. 1. Pergamon Press, Oxford (1989)
Miller, W., Geselowitz, D.: Simulation studies of the electrocardiogram. I. The normal heart. Circ. Res. 43, 301–315 (1978)
Avbelj, V., Trobec, R., Gersak, B.: Beat-to-beat repolarisation variability in body surface electrocardiograms. Med. Biol. Eng. Comput. 41(5), 556–560 (2003)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Trobec, R., Depolli, M., Avbelj, V. (2010). Simulation of ECG Repolarization Phase with Improved Model of Cell Action Potentials. In: Fred, A., Filipe, J., Gamboa, H. (eds) Biomedical Engineering Systems and Technologies. BIOSTEC 2009. Communications in Computer and Information Science, vol 52. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11721-3_25
Download citation
DOI: https://doi.org/10.1007/978-3-642-11721-3_25
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-11720-6
Online ISBN: 978-3-642-11721-3
eBook Packages: Computer ScienceComputer Science (R0)