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Combinatorics in Recombinational Population Genomics

(Invited Keynote Talk)

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Bioinformatics Research and Applications (ISBRA 2010)

Part of the book series: Lecture Notes in Computer Science ((LNBI,volume 6053))

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Abstract

The work that I will discuss is motivated by the need for understanding, and processing, the manifestations of recombination events in chromosome sequences. In this talk, we focus on two related problems. First, we explore the very general problem of reconstructability of pedigree history. How plausible is it to unravel the history of a complete unit (chromosome) of inheritance? The second problem deals with reconstructing the recombinational history of a collection of chromosomes.

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References

  1. Griffiths, R.C., Marjoram, P.: An ancestral recombinations graph. In: Donnelly, P., Tavare, S. (eds.) Progress in Population Genetics and Human Evolution, IMA vols in Mathematics and its Applications, vol. 87, pp. 257–270 (1997)

    Google Scholar 

  2. Gabriel, S.B., Schaffner, S.F., Nguyen, H., Moore, J.M., Roy, J., Blumenstiel, B., Higgins, J., De Felice, M., Lochner, A., Faggart, M., Liu-Cordero, S.N., Rotimi, C., Adeyemo, A., Cooper, R., Ward, R., Lander, E.S., Daly, M.J., Altshuler, D.: The structure of haplotype blocks in the human genome. Science 296(5576), 2225–2229 (2002)

    Article  Google Scholar 

  3. Hudson, R.R.: Gene genealogies and the coalescent process. In: Oxford Surveys in Evolutionary Biology. Oxford University Press, Oxford (1990)

    Google Scholar 

  4. Hein, J., Schierup, M.H., Wiuf, C.: Gene Genealogies, Variation and Evolution: A Primer in Coalescent Theory. Oxford Press, Oxford (2005)

    MATH  Google Scholar 

  5. Melé, M., Javed, A., Calafell, F., Parida, L., Bertranpetit, J.: Genographic Consortium. Recombination-based genomics: a genetic variation analysis in human populations (2009) (under submission)

    Google Scholar 

  6. Parida, L.: Ancestral Recombinations Graph: A Reconstructability Perspective using Random-Graphs Framework (2009) (under submission)

    Google Scholar 

  7. Parida, L., Javed, A.: Coalescence with Recombinations: Combinatorial Construction of ARGs (2010) (under submission)

    Google Scholar 

  8. Parida, L., Melé, M., Calafell, F., Bertranpetit, J.: Genographic Consortium. Estimating the Ancestral Recombinations Graph (ARG) as Compatible Networks of SNP Patterns. Journal of Computational Biology 15(9), 1–22 (2008)

    Article  MathSciNet  Google Scholar 

  9. Parida, L., Melé, M., Calafell, F., Bertranpetit, J.: Genographic Consortium. Minimizing recombinations in consensus networks for phylogeographic studies. BMC Bioinformatics 10(1), S72 (2009) doi = 10.1186/1471-2105-10-S1-S72

    Article  Google Scholar 

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Parida, L. (2010). Combinatorics in Recombinational Population Genomics. In: Borodovsky, M., Gogarten, J.P., Przytycka, T.M., Rajasekaran, S. (eds) Bioinformatics Research and Applications. ISBRA 2010. Lecture Notes in Computer Science(), vol 6053. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-13078-6_15

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  • DOI: https://doi.org/10.1007/978-3-642-13078-6_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-13077-9

  • Online ISBN: 978-3-642-13078-6

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