Abstract
We present a physiologically plausible spiking neuron-level model of the superior colliculus as part of the saccade-generating visual system. Two major features of the area are the bursting behavior of its output neurons that drive eye movements, and the spreading neuron activation in the intermediate layer during a saccade. We show that the bursting activity profile that drives the main sequence behavior of saccadic eye movements can be generated by a combination of NMDA and cholinergic receptors driven by a local circuit. We also show how the long-range spreading activation can occur, and propose that the functional role for this mechanism is to track the general activity level and trigger a system-wide reset at the end of a saccade.
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References
Choi, W.Y., Guitton, D.: Firing patterns in superior colliculus of Head-Unrestrained monkey during normal and perturbed gaze saccades reveal Short-Latency feedback and a sluggish rostral shift in activity. J. Neurosci. 29(22), 7166–7180 (2009)
Girard, B., Berthoz, A.: From brainstem to cortex: Computational models of saccade generation circuitry. Progress in Neurobiology 77(4), 215–251 (2005)
Sparks, D.L.: The brainstem control of saccadic eye movements. Nature Reviews Neuroscience 3(12), 952–964 (2002)
Zhu, J.J., Lo, F.: Recurrent inhibitory circuitry in the deep layers of the rabbit superior colliculus. The Journal of Physiology 523(3), 731–740 (2000)
Hikosaka, O., Takikawa, Y., Kawagoe, R.: Role of the basal ganglia in the control of purposive saccadic eye movements. Physiol. Rev. 80(3), 953–978 (2000)
Saito, Y., Isa, T.: Organization of interlaminar interactions in the rat superior colliculus. J. Neurophysiol. 93(5), 2898–2907 (2005)
Aizawa, H., Kobayashi, Y., Yamamoto, M., Isa, T.: Injection of nicotine into the superior colliculus facilitates occurrence of express saccades in monkeys. J. Neurophysiol. 82(3), 1642–1646 (1999)
Saito, Y., Isa, T.: Local excitatory network and NMDA receptor activation generate a synchronous and bursting command from the superior colliculus. J. Neurosci. 23(13), 5854–5864 (2003)
Cromer, J.A., Waitzman, D.M.: Comparison of Saccade-Associated neuronal activity in the primate central mesencephalic and paramedian pontine reticular formations. J. Neurophysiol. 98(2), 835–850 (2007)
Zhou, L., Warren, S., May, P.: The feedback circuit connecting the central mesencephalic reticular formation and the superior colliculus in the macaque monkey: tectal connections. Experimental Brain Research 189(4), 485–496 (2008)
Isa, T., Hall, W.C.: Exploring the superior colliculus in vitro. J. Neurophysiol. 102(5), 2581–2593 (2009)
Nakahara, H., Morita, K., Wurtz, R.H., Optican, L.M.: Saccade-Related spread of activity across superior colliculus arise from asymmetry of internal connections. J. Neurophysiol. 96(2), 765–774 (2006)
Soetedjo, R., Kaneko, C.R.S., Fuchs, A.F.: Evidence against a moving hill in the superior colliculus during saccadic eye movements in the monkey. J. Neurophysiol. 87(6), 2778–2789 (2002)
van Opstal, A., Goossens, H.: Linear ensemble-coding in midbrain superior colliculus specifies the saccade kinematics. Biological Cybernetics 98(6), 561–577 (2008)
Soetedjo, R., Kaneko, C.R.S., Fuchs, A.F.: Evidence that the superior colliculus participates in the feedback control of saccadic eye movements. J. Neurophysiol. 87(2), 679–695 (2002)
Goossens, H., Opstal, A.J.V.: Blink-Perturbed saccades in monkey. II. superior colliculus activity. J. Neurophysiol. 83(6), 3430–3452 (2000)
Brette, R., Gerstner, W.: Adaptive exponential Integrate-and-Fire model as an effective description of neuronal activity. J. Neurophysiol. 94(5), 3637–3642 (2005)
Gewaltig, M.O., Diesmann, M.: Nest (neural simulation tool). Scholarpedia 2(4), 1430 (2007)
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Morén, J., Shibata, T., Doya, K. (2010). Toward a Spiking-Neuron Model of the Oculomotor System. In: Doncieux, S., Girard, B., Guillot, A., Hallam, J., Meyer, JA., Mouret, JB. (eds) From Animals to Animats 11. SAB 2010. Lecture Notes in Computer Science(), vol 6226. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-15193-4_10
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DOI: https://doi.org/10.1007/978-3-642-15193-4_10
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-15192-7
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