Abstract
In this paper we propose a method to retrieve combinatorial protein-protein interaction to predict the interaction networks from protein expression data based on statistics on conditional probability. Our method retrieves the combinations of three proteins A, B and C which include combinatorial effects among them. The combinatorial effect considered in this paper does not include the ”sole effect” between two proteins A-C or B-C, so that we can retrieve the combinatorial effect which appears only when proteins A, B and C get together. We evaluate our method with a real protein expression data set and obtain several combinations of three proteins in which protein-protein interactions are prediced.
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Fujiki, T., Inoue, E., Yoshihiro, T., Nakagawa, M. (2010). Prediction of Combinatorial Protein-Protein Interaction Networks from Expression Data Using Statistics on Conditional Probability. In: Setchi, R., Jordanov, I., Howlett, R.J., Jain, L.C. (eds) Knowledge-Based and Intelligent Information and Engineering Systems. KES 2010. Lecture Notes in Computer Science(), vol 6278. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-15393-8_57
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DOI: https://doi.org/10.1007/978-3-642-15393-8_57
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-15392-1
Online ISBN: 978-3-642-15393-8
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