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Encapsulated Multi-vesicle Assemblies of Programmable Architecture: Towards Personalized Healthcare

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Book cover Biomedical Engineering Systems and Technologies (BIOSTEC 2010)

Part of the book series: Communications in Computer and Information Science ((CCIS,volume 127))

Abstract

Although single artificial vesicles are successfully used as delivery vehicles of pharmaceuticals, unilamellarity and restriction to one vessel result in premature content release in physiological environments as well as problems in simultaneous entrapment of a given set of (pharmaceutical) components. Multilamellarity and assemblies of distinct populations of vesicles are proposed to solve these problems. In this study, we provide a novel encapsulation protocol to fabricate multilamellar vesicles and we report on the DNA-mediated self-assembly of more than two distinct populations of vesicles. We discuss how these results might be used in personalized healthcare based on custom-tailored encapsulated multicompartment vesicular drug delivery systems.

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Authors and Affiliations

  1. Department of Informatics, Artificial Intelligence Laboratory, University of Zurich, Zurich, Switzerland

    Maik Hadorn

  2. The Mærsk Mc-Kinney Møller Institute, University of Southern Denmark, Odense M, Denmark

    Peter Eggenberger Hotz

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  1. Maik Hadorn
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  2. Peter Eggenberger Hotz
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Editors and Affiliations

  1. IST - Technical University of Lisbon, Av.Rovisco Pais, 1, 1049-001, Lisbon, Portugal

    Ana Fred

  2. Departament of Systems and Informatics, Polytechnic Institute of Setúbal – INSTICC, Rua do Vale de Chaves - Estefanilha, 2910-761, Setúbal, Portugal

    Joaquim Filipe

  3. Institute of Telecommunications, Av. Rovisco Pais, 1, 1049-001, Lisboa, Portugal

    Hugo Gamboa

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Hadorn, M., Eggenberger Hotz, P. (2011). Encapsulated Multi-vesicle Assemblies of Programmable Architecture: Towards Personalized Healthcare. In: Fred, A., Filipe, J., Gamboa, H. (eds) Biomedical Engineering Systems and Technologies. BIOSTEC 2010. Communications in Computer and Information Science, vol 127. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18472-7_11

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  • DOI: https://doi.org/10.1007/978-3-642-18472-7_11

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