Abstract
Since the initial demonstration of nerve excitation and the subsequent action potential generation by Hodgkin and Huxley in 1952, most efforts in modulating or restoring neural activity to cure diseases or injury have concentrated on using neural interfaces for electrical stimulation with electrodes. However, it was soon appreciated that repeated chronic stimulations necessary for lasting rehabilitation could have its drawbacks. Namely, the eventual degradation of tissue and electrodes, issues of biocompatibility and immune responses to foreign objects. Nevertheless, new innovative methods are emerging which can improve the quality and duration of neural stimulations. Here we review and suggest an alternative approach to modulate activity using optogenetics in therapy.
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Humphreys, L., Ferrández, J.M., Fernández, E. (2011). Long Term Modulation and Control of Neuronal Firing in Excitable Tissue Using Optogenetics. In: Ferrández, J.M., Álvarez Sánchez, J.R., de la Paz, F., Toledo, F.J. (eds) Foundations on Natural and Artificial Computation. IWINAC 2011. Lecture Notes in Computer Science, vol 6686. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-21344-1_28
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DOI: https://doi.org/10.1007/978-3-642-21344-1_28
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