Abstract
Volumetric breast density was determined using QuantraTM (Hologic) in 1356 women undergoing routine breast screening. Self-reported ethnicity, age, HRT use, weight and height were also available. 1038 women declared themselves to be White (British or Irish), 71 Black, 77 Asian, 91 Jewish, 31 Mixed Race and 48 Other European. Most of the Jewish group were Ashkenazi, a group in which there is a high probability of genetic susceptibility to breast cancer. Women with screen-detected or previous cancers were excluded. The only significant difference in breast density found between ethnic groups was between the Jewish women and women of White (British or Irish) ethnicity, where mean volumetric densities were 19.61% and 16.89% respectively (p=0.012), however this difference is only of borderline significance (p=0.053) once adjustments are made for age, Body Mass Index (BMI) and use of Hormone Replacement Therapy (HRT). The Jewish women had on average a lower BMI and were more likely to have used HRT.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Evans, D.G., Warwick, J., Astley, S.M., et al.: Assessing individual breast cancer risk within the UK National Health Service Breast Screening Programme: a new paradigm for cancer prevention. Cancer Prevention Research (forthcoming)
Howell, A., Astley, S., Warwick, J., et al.: Prevention of breast cancer in the context of a national breast screening programme. Journal of Internal Medicine 271, 321–330 (2012)
Tyrer, J., Duffy, S.W., Cuzick, J.: A breast cancer prediction model incorporating familial and personal risk factors. Stat. Med. 23, 1111–1130 (2004)
Boyd, N.F., Greenberg, C., Lockwood, G., et al.: Effects at two years of a low-fat, high-carbohydrate diet on radiologic features of the breast: Results from a randomized trial. Journal of the National Cancer Institute 89(7), 488–496 (1997)
Cummings, S.R., Tice, J.A., et al.: Prevention of Breast Cancer in Postmenopausal Women: Approaches to Estimating and Reducing Risk. Journal of the National Cancer Institute 101(6), 384–398 (2009)
2009 Ethnic Group Estimate by broad age and sex, Manchester City Council, http://www.manchester.gov.uk/downloads/download/4220/corporate_research_and_intelligence_population_publications (accessed April 16, 2012)
National Cancer Institute Surveillance Epidemiology and End Results, http://seer.cancer.gov/csr/1975_2009_pops09/results_merged/topic_race_ethnicity.pdf (accessed April 16, 2012)
Smigal, C., Jemal, A., Ward, E., et al.: Trends in Breast Cancer by Race and Ethnicity: Update 2006. Cancer J. Clin. 56(3), 169–187 (2006)
Li, C., Malone, K., Daling, J.: Differences in Breast Cancer Stage, Treatment, and Survival by Race and Ethnicity. Am. Med. Association (163), 49–56 (2003)
Jemal, A., Siegel, R., Xu, J.Q., Ward, E.: Cancer Statistics, 2010. Cancer J. Clin. 60(5), 277–300 (2010)
Shavers, V.L., Brown, M.L.: Racial and ethnic disparities in the receipt of cancer treatment. JNCI 94(5), 334–357 (2002)
Tzias, D., Wilkinson, L., Mehta, R., et al.: Correlation of Ethnicity with Breast Density as Assessed by QuantraTM. Breast Cancer Research 13(suppl. 1), O5 (2011)
El-Bastawissi, A.Y., White, E., Mandelson, M.T., Taplin, S.: Variation in mammographic breast density by race. Ann. Epidemiol. 11(4), 257–263 (2001)
Chen, Z., Wu, A.H., Gauderman, W.J., Bernstein, L., Ma, H., Pike, M.C., et al.: Does mammographic density reflect ethnic differences in breast cancer incidence rates? Am. J. Epidemiol. 159(2), 140–147 (2004)
Turnbull, A.E., Kapera, L., Cohen, M.E.L.: Mammographic Parenchymal Pattern in Asian and Caucasian Women Attending for Screening. Clin Radiology (48), 38–40 (1993)
del Carmen, M.G., Hughes, K.S., Halpern, E., Rafferty, E., Kopans, D., Parisky, Y.R., et al.: Racial differences in mammographic breast density. Cancer 98(3), 590–596 (2003)
Hartman, K., Highnam, R., Warren, R., Jackson, V.: Volumetric Assessment of Breast Tissue Composition from FFDM Images. In: Krupinski, E.A. (ed.) IWDM 2008. LNCS, vol. 5116, pp. 33–39. Springer, Heidelberg (2008)
Rosenberg, R.D., Hunt, W.C., Williamson, M.R., et al.: Effects of age, breast density, ethnicity, and estrogen replacement therapy on screening mammographic sensitivity and cancer stage at diagnosis: review of 183,134 screening mammograms in Albuquerque, New Mexico. Radiology 209, 511–518 (1998)
Struewing, J.P., Hartge, P., Wacholder, S., et al.: The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews. New England Journal of Medicine 336(20), 1401–1408 (1997)
Goel, M.S., Wee, C.C., McCarthy, E.P., et al.: Racial and ethnic disparities in cancer screening - The importance of foreign birth as a barrier to care. Journal of General Internal Medicine 18(12), 1028–1035 (2003)
Patel, H.G., Astley, S.M., Hufton, A.P., Harvie, M., Hagan, K., Marchant, T.E., Hillier, V., Howell, A., Warren, R., Boggis, C.R.M.: Automated Breast Tissue Measurement of Women at Increased Risk of Breast Cancer. In: Astley, S.M., Brady, M., Rose, C., Zwiggelaar, R. (eds.) IWDM 2006. LNCS, vol. 4046, pp. 131–136. Springer, Heidelberg (2006)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Hashmi, S. et al. (2012). Ethnic Variation in Volumetric Breast Density. In: Maidment, A.D.A., Bakic, P.R., Gavenonis, S. (eds) Breast Imaging. IWDM 2012. Lecture Notes in Computer Science, vol 7361. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-31271-7_17
Download citation
DOI: https://doi.org/10.1007/978-3-642-31271-7_17
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-31270-0
Online ISBN: 978-3-642-31271-7
eBook Packages: Computer ScienceComputer Science (R0)