Skip to main content

Biomedical Diagnosis Based on Ion Mobility Spectrometry – A Case Study Using Probabilistic Relational Modelling and Learning

  • Conference paper
  • 1263 Accesses

Part of the book series: Communications in Computer and Information Science ((CCIS,volume 300))

Abstract

Aiming at providing a non-invasive and easy-to-use method for the early detection of bronchial carcinoma, it has been proposed to apply ion mobility spectrometry (IMS) to the breath a person exhales. Extending previous work using such IMS data, we report on a case study using methods of probabilistic relational modelling and learning. By taking additional features of an IMS measurement into account and using refined clustering and modelling methods, inference accuracy is increased.

The research reported here was partially supported by the DFG (BE 1700/7-2).

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Baumbach, J.I., Westhoff, M.: Ion mobility spectometry to detect lung cancer and airway infections. Spectroscopy Europe 18(6), 22–27 (2006)

    Google Scholar 

  2. Brier, G.W.: Verification of forecasts expressed in terms of probability. Monthly Weather Review 78(1), 1–3 (1950)

    Article  Google Scholar 

  3. Finthammer, M., Beierle, C., Fisseler, J., Kern-Isberner, G., Baumbach, J.I.: Using probabilistic relational learning to support bronchial carcinoma diagnosis based on ion mobility spectrometry. International Journal for Ion Mobility Spectrometry 13, 83–93 (2010)

    Article  Google Scholar 

  4. Finthammer, M., Beierle, C., Fisseler, J., Kern-Isberner, G., Möller, B., Baumbach, J.I.: Probabilistic Relational Learning for Medical Diagnosis Based on Ion Mobility Spectrometry. In: Hüllermeier, E., Kruse, R., Hoffmann, F. (eds.) IPMU 2010. CCIS, vol. 80, pp. 365–375. Springer, Heidelberg (2010)

    Chapter  Google Scholar 

  5. Getoor, L., Taskar, B. (eds.): Introduction to Statistical Relational Learning. MIT Press (2007)

    Google Scholar 

  6. Kok, S., Singla, P., Richardson, M., Domingos, P., Sumner, M., Poon, H., Lowd, D., Wang, J.: The Alchemy System for Statistical Relational AI: User Manual. Department of Computer Science and Engineering. University of Washington (2008)

    Google Scholar 

  7. Lindeberg, T.: Scale-space. In: Wah, B.W. (ed.) Wiley Encyclopedia of Computer Science and Engineering. John Wiley & Sons, Inc. (2008)

    Google Scholar 

  8. MacQueen, J.B.: Some methods of classification and analysis of multivariate observations. In: Proceedings of the Fifth Berkeley Symposium on Mathematical Statistics and Probability, pp. 281–297 (1967)

    Google Scholar 

  9. Masternak, R.: Application of probabilistic relational learning for the analysis of multidimensional, spectrometric data. Master Thesis, Dept. of Computer Science, FernUniversität in Hagen, Germany (2011) (in German)

    Google Scholar 

  10. Muggleton, S., De Raedt, L.: Inductive logic programming: Theory and methods. Journal of Logic Programming 19/20, 629–679 (1994)

    Article  Google Scholar 

  11. Pearl, J.: Probabilistic Reasoning in Intelligent Systems: Networks of Plausible Inference. Morgan Kaufmann (1988)

    Google Scholar 

  12. Richardson, M., Domingos, P.: Markov logic networks. Machine Learning 62(1), 107–136 (2006)

    Article  Google Scholar 

  13. Srinivasan, A.: The Aleph Manual (2007), www.comlab.ox.ac.uk/activities/machinelearning/Aleph/

  14. Yu, W., Li, X., Liu, J., Wu, B., Williams, K.R., Zhao, H.: Multiple peak alignment in sequential data analysis: A scale-space-based approach. IEEE/ACM Trans. Comput. Biology Bioinform. 3(3), 208–219 (2006)

    Article  Google Scholar 

  15. Zhou, X.-H., McClish, D.K., Obuchowski, N.A.: Statistical Methods in Diagnostic Medicine, 2nd edn. Wiley, Hoboken (2011)

    Book  MATH  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Finthammer, M., Masternak, R., Beierle, C. (2012). Biomedical Diagnosis Based on Ion Mobility Spectrometry – A Case Study Using Probabilistic Relational Modelling and Learning. In: Greco, S., Bouchon-Meunier, B., Coletti, G., Fedrizzi, M., Matarazzo, B., Yager, R.R. (eds) Advances in Computational Intelligence. IPMU 2012. Communications in Computer and Information Science, vol 300. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-31724-8_69

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-31724-8_69

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-31723-1

  • Online ISBN: 978-3-642-31724-8

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics