Abstract
The cerebellum has two distinct memory sites. A single session of behavioral training forms short-term memory in the cerebellar cortex, and by repeating the training, long-term memory is formed in the cerebellar or vestibular nuclei, as if the memory is transferred from the cortex to the nuclei. We propose a simple network model of the cerebellum for the formation and transfer of motor memory. We assume a Hebbian rule with a postsynaptic gating mechanism for synaptic plasticity in the nuclei. We carry out computer simulation of gain adaptation of vestibulo-ocular reflex (VOR) and demonstrate robust memory transfer: the synaptic weight in the nuclei does not diverge to infinity. We suggest that memory transfer occurs mainly after training, not during training, and that spontaneous activity of Purkinje cells after training is necessary for memory transfer.
This study was supported by KAKENHI (20700301) and an internal startup fund of the University of Electro-Communications.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Melvill, J.G.: Motor learning in vestibulo-ocular control. In: Kandel, E.R., Schwartz, J.H., Jessell, T.M. (eds.) Principles of Neural Science, pp. 824–828. McGraw-Hill (2000)
DufosséIto, M., Jastreboff, P.J.M., Miyashita, Y.: A neuronal correlate in rabbit’s cerebellum to adaptive modification of the vestibulo-ocular reflex. Brain Res. 150, 611–616 (1978)
Miles, F.A.: Lisberger SG Plasticity in vestibulo-ocular reflex: a new hypothesis. Ann. Rev. Neurosci. 4, 273–299 (1981)
Ito, M.: Cerebellar control of the vestibulo-ocular reflex-Around the flocculus hypothesis. Ann. Rev. Neurosci. 5, 275–297 (1982)
Nagao, S., Kitazawa, H.: Effects of reversible shutdown of the monkey flocculus on the retention of adaptation of the horizontal vestibulo-ocular reflex. Neuroscience 118, 563–570 (2003)
Kassardjian, C.D., Tan, Y.F., Chung, J.Y., Heskin, R., Peterson, M.J., Broussard, D.M.: The site of a motor memory shifts with consolidation. J. Neurosci. 25, 7979–7985 (2005)
Shutoh, F., Ohki, M., Kitazawa, H., Itohara, S., Nagao, S.: Memory trace of motor learning shifts transsynaptically from cerebellar cortex to nuclei for consolidation. Neurosci. 139, 767–777 (2006)
Anzai, M., Kitazawa, H., Nagao, S.: Effects of reversible pharmacological shutdown of cerebellar flocculus on the memory of long-term horizontal vestibulo-ocular reflex adaptation in monkeys. Neurosci. Res. 68, 191–198 (2010)
Attwell, P.J.E., Cook, S.F., Yeo, C.H.: Cerebellar Function in Consolidation of a Motor Memory. Neuron 34, 1011–1020 (2002)
Okamoto, T., Endo, S., Shirao, T., Nagao, S.: Role of cerebellar cortical protein synthesis in transfer of memory trace of cerebellum-dependent motor learning. J. Neurosci. 31, 8958–8966 (2011)
Okamoto, T., Shirao, T., Shutoh, F., Suzuki, T., Nagao, S.: Post-training cerebellar cortical activity plays an important role for consolidation of memory of cerebellum-dependent motor learning. Neurosci. Lett. 504, 53–56 (2011)
Ito, M.: Long-term depression. Ann. Rev. Neurosci. 12, 85–102 (1989)
Gerstner, W., Kistler, W.: Spiking Neuron Models. Cambridge University Press (2002)
Medina, J.F., Mauk, M.D.: Simulations of cerebellar motor learning: Computational analysis of plasticity at the mossy fiber to deep cerebellar nucleus. J. Neurosci. 19, 7140–7151 (1999)
Masuda, N., Amari, S.: A computational study of synaptic mechanisms of partial memory transfer in cerebellar vestibulo-ocular-reflex learning. J. Comput. Neurosci. 24, 137–156 (2008)
Ezure, K., Schor, R.H., Yoshida, K.: The response of horizontal semicircular canal afferents to sinusoidal rotation in the cat. Exp. Brain Res. 33, 27–39 (1978)
Linden, D.J.: A protein synthesis-dependent late phase of cerebellar long-term depression. Neuron. 17, 483–490 (1996)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Yamazaki, T., Nagao, S. (2012). Modeling Post-training Memory Transfer in Cerebellar Motor Learning. In: Huang, T., Zeng, Z., Li, C., Leung, C.S. (eds) Neural Information Processing. ICONIP 2012. Lecture Notes in Computer Science, vol 7665. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-34487-9_51
Download citation
DOI: https://doi.org/10.1007/978-3-642-34487-9_51
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-34486-2
Online ISBN: 978-3-642-34487-9
eBook Packages: Computer ScienceComputer Science (R0)