Abstract
The function of the parahippocampal place area (PPA) is a matter of debate. We investigated this issue in fMRI experiment by 36 normal subjects using two types of tasks: figure and text. Furthermore, the figure tasks contain two kinds of contextual associations: one is among items; the other is among items and their locations which refers to the spatial contextual associations. In contrast, the text tasks contain only item contextual associations - they do not have any spatial information. The results showed that the right PPA located at anterior lingual gyrus and left anterior parahippocampal gyrus nearby amygdala were significantly activated during both figure and text tasks, which indicate that the PPA is more involved in associative information processing.
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References
Gabrieli, J., Brewer, J.B., Desmond, J.E., Glover, G.H.: Separate neural bases of two fundamental memory processes in the human medial temporal lobe. Science 276, 264–266 (1997)
Henke, K., Buck, A., Weber, B., Wieser, H.G.: Human hippocampus establishes associations in memory. Hippocampus 7, 249–256 (1997)
Henke, K., Weber, B., Kneifel, S., Wieser, H.G., Buck, A.: Human hippocampus associates information in memory. PNAS 96, 5884–5889 (1999)
Dobbins, I.G., Rice, H.J., Wagner, A.D., Schacter, D.L.: Memory orientation and success: separable neurocognitive components underlying episodic recognition. Neuropsychologia 41, 318–333 (2003)
Sommer, T., Rose, M., Weiller, C., Buchel, C.: Contributions of occipital, parietal and parahippocampal cortex to encoding of object-location associations. Neuropsychologia 43, 732–743 (2005)
Bird, C.M., Burgess, N.: The hippocampus and memory: insights from spatial processing. Nat. Rev. Neurosci. 9, 182–194 (2008)
Aguirre, G.K., Detre, J.A., Alsop, D.C., DEsposito, M.: The parahippocampus subserves topographical learning in man. Cereb. Cortex 6, 823–829 (1996)
Maguire, E.A., Frackowiak, R., Frith, C.D.: Recalling routes around London: Activation of the right hippocampus in taxi drivers. J. Neurosci. 17, 7103–7110 (1997)
Mellet, E., Bricogne, S., Tzourio-Mazoyer, N., Ghaem, O., Petit, L., Zago, L., et al.: Neural correlates of topographic mental exploration: The impact of route versus survey perspective learning. Neuroimage 12, 588–600 (2000)
Levy, I., Hasson, U., Avidan, G., Hendler, T., Malach, R.: Center-periphery organization of human object areas. Nat. Neurosci. 4, 533–539 (2000)
Goh, J.O., Siong, S.C., Park, D., Gutchess, A., Hebrank, A., Chee, M.W.: Cortical areas involved in object, background, and object-background processing revealed with functional magnetic resonance adaptation. J. Neurosci. 24, 10223–10228 (2004)
Yi, D.J., Chun, M.M.: Attentional modulation of learning-related repetition attenuation effects in human parahippocampal cortex. J. Neurosci. 25, 3593–3600 (2005)
Epstein, R., Kanwisher, N.: A cortical representation of the local visual environment. Nature 392, 598–601 (1998)
Epstein, R., Harris, A., Stanley, D., Kanwisher, N.: The parahippocampal place area: Recognition, navigation, or encoding? Neuron 23, 115–125 (1999)
Ghaem, O., Mellet, E., Crivello, F., Tzourio, N., Mazoyer, B., Berthoz, A., et al.: Mental navigation along memorized routes activates the hippocampus, precuneus, and insula. Neuroreport 8, 739–744 (1997)
Rosenbaum, R.S., Ziegler, M., Winocur, G., Grady, C.L., Moscovitch, M.: I have often walked down this street before: fMRI studies on the hippocampus and other structures during mental navigation of an old environment. Hippocampus 14, 826–835 (2004)
O’Craven, K.M., Kanwisher, N.: Mental imagery of faces and places activates corresponding stimulus-specific brain regions. J. Cognitive Neurosci. 12, 1013–1023 (2000)
Aguirre, G.K., D’Esposito, M.: Topographical disorientation: a synthesis and taxonomy. Brain 122, 1613–1628 (1999)
Epstein, R., DeYoe, E.A., Press, D.Z., Rosen, A.C., Kanwisher, N.: Neuropsychological evidence for a topographical learning mechanism in parahippocampal cortex. Cogn. Neuropsychol. 18, 481–508 (2001)
Mendez, M.F., Cherrier, M.M.: Agnosia for scenes in topographagnosia. Neuropsychologia 41, 1387–1395 (2003)
Bar, M., Aminoff, E.: Cortical analysis of visual context. Neuron 38, 347–358 (2003)
Aminoff, E., Gronau, N., Bar, M.: The parahippocampal cortex mediates spatial and nonspatial associations. Cereb Cortex 17, 1493–1503 (2007)
Yonelinas, A.P., Hopfinger, J.B., Buonocore, M.H., Kroll, N., Baynes, K.: Hippocampal, parahippocampal and occipital-temporal contributions to associative and item recognition memory: an fMRI study. Neuroreport 12, 359–363 (2001)
Epstein, R.A., Ward, E.J.: How Reliable Are Visual Context Effects in the Parahippocampal Place Area? Cereb Cortex 20, 294–303 (2010)
Bar, M., Aminoff, E., Schacter, D.L.: Scenes unseen: The parahippocampal cortex intrinsically subserves contextual associations, not scenes or places per se. J. Neurosci. 28, 8539–8544 (2008)
St George, M., Kutas, M., Martinez, A., Sereno, M.I.: Semantic integration in reading: engagement of the right hemisphere during discourse processing. Brain 122, 1317–1325 (1999)
Mou, W.M., McNamara, T.P.: Intrinsic frames of reference in spatial memory. J. Exp. Psychol. Learn. 28, 162–170 (2002)
Wang, R.F., Spelke, E.S.: Human spatial representation: Insights from animals - Ranxiao Frances Wang and Elizabeth S. Spelke. Trends Cogn. Sci. 6, 376–382 (2002)
Murray, E.A., Bussey, T.J.: Perceptual-mnemonic functions of the perirhinal cortex. Trends Cogn. Sci. 3, 142–151 (1999)
Sperling, R., Chua, E., Cocchiarella, A., Rand-Giovannetti, E., Poldrack, R., Schacter, D.L., et al.: Putting names to faces: Successful encoding of associative memories activates the anterior hippocampal formation. Neuroimage 20, 1400–1410 (2003)
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Li, M., Han, D., Lu, S., Liu, Z., Zhong, N. (2012). Associative Information Processing in Parahippocampal Place Area (PPA): An fMRI Study. In: Zanzotto, F.M., Tsumoto, S., Taatgen, N., Yao, Y. (eds) Brain Informatics. BI 2012. Lecture Notes in Computer Science(), vol 7670. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35139-6_1
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DOI: https://doi.org/10.1007/978-3-642-35139-6_1
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