Abstract
We propose a methodology to estimate 3D+time maps of left ventricular (LV) fibre strain from human structural and dynamic MRI data. A biomechanical finite element model integrates fibre direction throughout the LV extracted from ex vivo human diffusion tensor MRI (DT-MRI) acquisition and motion tracked from tagged MRI (TMRI). This combination enables the estimation of fibre strain and its spatio-temporal variation throughout the cardiac cycle. The sensitivity of fibre strain estimation on the underlying fibre orientation is evaluated using a database of 7 DT-MRI and 1 TMRI datasets acquired on normal subjects. Our analysis indicates that the structure of the LV is designed for maximum homogeneity of fibre strain during ejection.
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Casta, C. et al. (2013). Estimation of In Vivo Myocardial Fibre Strain Using an Architectural Atlas of the Human Heart. In: Ourselin, S., Rueckert, D., Smith, N. (eds) Functional Imaging and Modeling of the Heart. FIMH 2013. Lecture Notes in Computer Science, vol 7945. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38899-6_25
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DOI: https://doi.org/10.1007/978-3-642-38899-6_25
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