Abstract
The aortic valve owes its strength and durability to a network of collagen fibers within the leaflets. However, the pattern of these fibers and their role in valve function is not well understood. We imaged and quantified the macroscopically visible pattern of collagen fibers in seven porcine aortic valves with particular attention to measuring this pattern in the unstrained leaflet. We then used a structural finite element model of the aortic valve to study the effect of the observed collagen pattern on the configuration of the loaded valve. Results showed that collagen is oriented oblique to the free edge over much of the leaflet in its unstrained state, and simulations suggest that this architecture plays an important role by enabling adequate valve leaflet coaptation. Simulation results were validated by comparison with images of a porcine aortic valve under load.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Augoustides, J.G., Szeto, W.Y., Bavaria, J.E.: Advances in aortic valve repair: focus on functional approach, clinical outcomes, and central role of echocardiography. J. Cardiothorac. Vasc. Anesth. 24, 1016–1020 (2010)
De Hart, J., Peters, G.W.M., Schreurs, P.J.G., Baaijens, F.P.T.: Collagen fibers reduce stresses and stabilize motion of aortic valve leaflets during systole. J. Biomech. 37, 303–311 (2004)
Sacks, M.S., Yoganathan, A.P.: Heart valve function: a biomechanical perspective. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 362, 1369–1391 (2007)
Sauren, A.A.H.J., Kuijpers, W., van Steenhoven, A.A., Veldpaus, F.E.: Aortic valve histology and its relation with mechanics—Preliminary report. J. Biomech. 13, 97–104 (1980)
Hammer, P.E., Chen, P.C., del Nido, P.J., Howe, R.D.: Computational model of aortic valve surgical repair using grafted pericardium. J. Biomech. 45, 1199–1204 (2012)
Köthe, U.: Edge and junction detection with an improved structure tensor. In: Michaelis, B., Krell, G. (eds.) DAGM 2003. LNCS, vol. 2781, pp. 25–32. Springer, Heidelberg (2003)
Liu, Y., Kasyanov, V., Schoephoerster, R.T.: Effect of fiber orientation on the stress distribution within a leaflet of a polymer composite heart valve in the closed position. J. Biomech. 40, 1099–1106 (2007)
Hammer, P.E., Howe, R.D., del Nido, P.J.: Lower transient stresses in an aortic valve leaflet with oblique reinforcement fibers: a finite element study. In: Proceedings of the ASME Summer Bioengineering Conf., Fajardo, PR, June 20-23 (2012)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Hammer, P.E., Pacak, C.A., Howe, R.D., del Nido, P.J. (2013). Collagen Bundle Orientation Explains Aortic Valve Leaflet Coaptation. In: Ourselin, S., Rueckert, D., Smith, N. (eds) Functional Imaging and Modeling of the Heart. FIMH 2013. Lecture Notes in Computer Science, vol 7945. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-38899-6_48
Download citation
DOI: https://doi.org/10.1007/978-3-642-38899-6_48
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-38898-9
Online ISBN: 978-3-642-38899-6
eBook Packages: Computer ScienceComputer Science (R0)