Abstract
By nature, healthcare data is highly complex and voluminous. While on one hand, it provides unprecedented opportunities to identify hidden and unknown relationships between patients and treatment outcomes, or drugs and allergic reactions for given individuals, representing and querying large network datasets poses significant technical challenges. In this research, we study the use of Semantic Web and Linked Data technologies for identifying potential drug-drug interaction (PDDI) information from publicly available resources, and determining if such interactions were observed using real patient data. Specifically, we apply Linked Data principles and technologies for representing patient data from electronic health records (EHRs) at Mayo Clinic as Resource Description Framework (RDF), and identify PDDIs for widely prescribed anti-coagulant Warfarin. Our results from the proof-of-concept study demonstrate the potential of applying such a methodology to study prescription trends based on gender and age as well as patient health outcomes.
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Pathak, J., Kiefer, R.C., Chute, C.G. (2013). Mining Anti-coagulant Drug-Drug Interactions from Electronic Health Records Using Linked Data. In: Baker, C.J.O., Butler, G., Jurisica, I. (eds) Data Integration in the Life Sciences. DILS 2013. Lecture Notes in Computer Science(), vol 7970. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39437-9_11
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DOI: https://doi.org/10.1007/978-3-642-39437-9_11
Publisher Name: Springer, Berlin, Heidelberg
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