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Possible miRNA Coregulation of Target Genes in Brain Regions by Both Differential miRNA Expression and miRNA-Targeting-Specific Promoter Methylation

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Book cover Emerging Intelligent Computing Technology and Applications (ICIC 2013)

Part of the book series: Communications in Computer and Information Science ((CCIS,volume 375))

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Abstract

We computationally reanalyzed public domain data set deposited to gene expression omnibus, of mRNA expression, miRNA expression and promoter methylation pattern in four brain regions, i.e., frontal cortex, temporal cortex, pons and cerebellum. Then we found that more than hundreds of both miRNA regulation of target genes and miRNA-targeting-specific promoter methylation are significant on all six pairwise comparisons among the above mentioned four brain regions. We also showed that some of miRNA regulation of target genes is highly correlated with both or either of miRNA-targeting-specific promoter methylation and differential miRNA expression. We concluded that the combinatorial analysis of miRNA regulation of target genes, miRNA-targeting-specific promoter methylation and differential miRNA expression can figure out brain region specific contribution of miRNAsto brain functions and developments.

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Authors and Affiliations

  1. Department of Physics, Chuo University, Kasuga, Bunkyo-ku, Tokyo, 112-8551, Japan

    Y. -H. Taguchi

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  1. Y. -H. Taguchi
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Editors and Affiliations

  1. Machine Learning and Systems Biology Laboratory, School of Electronics and Information Engineering, Tongji University, Shanghai, China

    De-Shuang Huang

  2. Department of Computer Science and Engineering, Indian Institute of Technology Kanpur, 208 016, Kanpur, India

    Phalguni Gupta

  3. Tsinghua University, Beijing, China

    Ling Wang

  4. Department of Biotechnology, Indian Institute of Technology Madras, 600 036, Chennai, Tamilnadu, India

    Michael Gromiha

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© 2013 Springer-Verlag Berlin Heidelberg

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Taguchi, Y.H. (2013). Possible miRNA Coregulation of Target Genes in Brain Regions by Both Differential miRNA Expression and miRNA-Targeting-Specific Promoter Methylation. In: Huang, DS., Gupta, P., Wang, L., Gromiha, M. (eds) Emerging Intelligent Computing Technology and Applications. ICIC 2013. Communications in Computer and Information Science, vol 375. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39678-6_38

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  • DOI: https://doi.org/10.1007/978-3-642-39678-6_38

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-39677-9

  • Online ISBN: 978-3-642-39678-6

  • eBook Packages: Computer ScienceComputer Science (R0)

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