Abstract
Preparing a sample with a specified concentration factor (CF) is an important step in automating biochemical laboratory protocols on a digital microfluidic biochip. In this paper, we address an open problem of sample preparation with a target CF in minimum number of mix/split steps when droplets of the same fluid are supplied with multiple CFs . We formulate this as a variant of the subset-sum problem and present a heuristic algorithm based on dynamic programming.
This work of S. Roy was supported by Microsoft Corporation and Microsoft Research India under the Microsoft Research India PhD Fellowship Award (2010-2014). The work of S. Ghoshal was supported in part by the Department of Science & Technology (DST) Women Scientists Scheme (WOS-A), 2009-2012. The work of K. Chakrabarty was supported in part by the US National Science Foundation under grants CCF-0914895 and CNS-1135853.
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Roy, S., Bhattacharya, B.B., Ghoshal, S., Chakrabarty, K. (2013). On-Chip Dilution from Multiple Concentrations of a Sample Fluid Using Digital Microfluidics. In: Gaur, M.S., Zwolinski, M., Laxmi, V., Boolchandani, D., Sing, V., Sing, A.D. (eds) VLSI Design and Test. Communications in Computer and Information Science, vol 382. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-42024-5_33
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DOI: https://doi.org/10.1007/978-3-642-42024-5_33
Publisher Name: Springer, Berlin, Heidelberg
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