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Knowledge Discovery and Visualization of Clusters for Erythromycin Related Adverse Events in the FDA Drug Adverse Event Reporting System

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Book cover Interactive Knowledge Discovery and Data Mining in Biomedical Informatics

Part of the book series: Lecture Notes in Computer Science ((LNISA,volume 8401))

Abstract

In this paper, a research study to discover hidden knowledge in the reports of the public release of the Food and Drug Administration (FDA)’s Adverse Event Reporting System (FAERS) for erythromycin is presented. Erythromycin is an antibiotic used to treat certain infections caused by bacteria. Bacterial infections can cause significant morbidity, mortality, and the costs of treatment are known to be detrimental to health institutions around the world. Since erythromycin is of great interest in medical research, the relationships between patient demographics, adverse event outcomes, and the adverse events of this drug were analyzed. The FDA’s FAERS database was used to create a dataset for cluster analysis in order to gain some statistical insights. The reports contained within the dataset consist of 3792 (44.1%) female and 4798 (55.8%) male patients. The mean age of each patient is 41.759. The most frequent adverse event reported is oligohtdramnios and the most frequent adverse event outcome is OT(Other). Cluster analysis was used for the analysis of the dataset using the DBSCAN algorithm, and according to the results, a number of clusters and associations were obtained, which are reported here. It is believed medical researchers and pharmaceutical companies can utilize these results and test these relationships within their clinical studies.

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Author information

Authors and Affiliations

  1. Department of Computer Engineering, Faculty of Engineering & Architecture, Okan University, Istanbul, Turkey

    Pinar Yildirim

  2. Research Unit HCI, Institute for Medical Informatics, Statistics and Documentation, Medical University Graz, Auenbruggerplatz 2/V, A-8036, Graz, Austria

    Marcus Bloice & Andreas Holzinger

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  1. Pinar Yildirim
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  2. Marcus Bloice
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  3. Andreas Holzinger
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Editors and Affiliations

  1. Research Unit Human-Computer Interaction, Austrian IBM Watson Think Gruop, Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Auenbruggerplatz 2/V, 8036, Graz, Austria

    Andreas Holzinger

  2. IBM Life Sciences Discovery Centre, TECHNA for the Advancement of Technology for Health, Princess Margaret Cancer Centre, University Health Network, TMDT Room 11-314, 101 College Street, M5G 1L7, Toronto, ON, Canada

    Igor Jurisica

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Yildirim, P., Bloice, M., Holzinger, A. (2014). Knowledge Discovery and Visualization of Clusters for Erythromycin Related Adverse Events in the FDA Drug Adverse Event Reporting System. In: Holzinger, A., Jurisica, I. (eds) Interactive Knowledge Discovery and Data Mining in Biomedical Informatics. Lecture Notes in Computer Science, vol 8401. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-43968-5_6

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  • DOI: https://doi.org/10.1007/978-3-662-43968-5_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-43967-8

  • Online ISBN: 978-3-662-43968-5

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