Skip to main content

ROI Segmentation from Brain MR Images with a Fast Multilevel Thresholding

  • Conference paper
  • First Online:

Part of the book series: Advances in Intelligent Systems and Computing ((AISC,volume 459))

Abstract

A novel region of interest (ROI) segmentation for detection of Glioblastoma multiforme (GBM) tumor in magnetic resonance (MR) images of the brain is proposed using a two-stage thresholding method. We have defined multiple intervals for multilevel thresholding using a novel meta-heuristic optimization technique called Discrete Curve Evolution. In each of these intervals, a threshold is selected by bi-level Otsu’s method. Then the ROI is extracted from only a single seed initialization, on the ROI, by the user. The proposed segmentation technique is more accurate as compared to the existing methods. Also the time complexity of our method is very low. The experimental evaluation is provided on contrast-enhanced T1-weighted MRI slices of three patients, having the corresponding ground truth of the tumor regions. The performance measure, based on Jaccard and Dice indices, of the segmented ROI demonstrated higher accuracy than existing methods.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Notes

  1. 1.

    “Brain tumor image data used in this work were obtained from the MICCAI 2012 Challenge on Multimodal Brain Tumor Segmentation (http://www.imm.dtu.dk/projects/BRATS2012) organized by B. Menze, A. Jakab, S. Bauer, M. Reyes, M. Prastawa, and K. Van Leemput. The challenge database contains fully anonymized images from the following institutions: ETH Zurich, University of Bern, University of Debrecen, and University of Utah.

    Note: the images in this database have been skull stripped”.

References

  1. Bagci, U., Udupa, J.K., Mendhiratta, N., Foster, B., Xu, Z., Yao, J., Chen, X., Mollura, D.J.: Joint segmentation of anatomical and functional images: Applications in quantification of lesions from PET, PET-CT, MRI-PET, and MRI-PET-CT images. Med. Image Anal. 17, 929–945 (2013)

    Google Scholar 

  2. Bai, X., Latecki, L.J., Liu, W.Y.: Skeleton pruning by contour partitioning with discrete curve evolution. IEEE T. Pattern Ana. 29, 449–462 (2007)

    Article  Google Scholar 

  3. Banerjee, S., Mitra, S., Uma Shankar, B., Hayashi, Y.: A novel GBM saliency detection model using multi-channel MRI. PLoS ONE 11(1): e0146388 (2016), doi:10.1371/journal.pone.0146388

  4. Beucher, S., Meyer, F.: The morphological approach to segmentation: The watershed transformation. Opt. Eng. 34, 433–481 (1993)

    Google Scholar 

  5. Gatenby, R.A., Grove, O., Gillies, R.J.: Quantitative imaging in cancer evolution and ecology. Radiology 269(1), 8–14 (2013)

    Article  Google Scholar 

  6. Han, J., Kamber, M., Pei, J.: Data Mining Concepts and Techniques. Morgan kaufmann (2006)

    Google Scholar 

  7. Huang, D.Y., Wang, C.H.: Optimal multi-level thresholding using a two-stage Otsu optimization approach. Pattern Recogn. Lett. 30, 275–284 (2009)

    Article  Google Scholar 

  8. Klein, A., et al.: Evaluation of 14 nonlinear deformation algorithms applied to human brain MRI registration. Neuroimage 46, 786–802 (2009)

    Article  Google Scholar 

  9. Liang, Y.C., Cuevas, J.R.: An automatic multilevel image thresholding using relative entropy and meta-heuristic algorithms. Entropy 15, 2181–2209 (2013)

    Article  MATH  Google Scholar 

  10. Liao, P.S., Chen, T.S., C., P.C.: A fast algorithm for multilevel thresholding. Inf. Sci. Eng. 17, 713–727 (2001)

    Google Scholar 

  11. Liu, D., Yu, J.: Otsu method and k-means. In: Ninth International Conference on Hybrid Intelligent Systems (HIS’09). vol. 1, pp. 344–349. IEEE (2009)

    Google Scholar 

  12. Mitra, S., Uma Shankar, B.: Medical image analysis for cancer management in natural computing framework. Inform. Sciences 306, 111–131 (2015)

    Google Scholar 

  13. Otsu, N.: A thresholding selection method from gray-level histogram. IEEE T. Syst. Man. Cyb. 9, 62–66 (1979)

    Google Scholar 

  14. Pham, D.L., Xu, C., Prince, J.L.: Current methods in medical image segmentation. Annu. Rev. Biomed. Eng. 2, 315–337 (2000)

    Article  Google Scholar 

  15. Rosenkrantz, A.B., et al.: Clinical utility of quantitative imaging. Acad. Radiol. 22, 33–49 (2015)

    Article  Google Scholar 

  16. Sahoo, P.K., Soltani, S., Wong, A.K.C.: A survey of thresholding techniques. Comput. Vision Graph. 41, 233–260 (1988)

    Article  Google Scholar 

  17. Sezgin, M., Sankur, B.: Survey over image thresholding techniques and quantitative performance evaluation. Electron. Imaging 13, 146–165 (2004)

    Article  Google Scholar 

  18. Velazquez, E.R., Parmar, C., et al.: Volumetric CT-based segmentation of NSCLC using 3D-slicer. Scientific Reports 3 (2013)

    Google Scholar 

  19. Vezhnevets, V., Konouchine, V.: GrowCut: Interactive multi-label N-D image segmentation by cellular automata. In: Proc. of GraphiCon. pp. 150–156 (2005)

    Google Scholar 

  20. Withey, D.J., Koles, Z.J.: A review of medical image segmentation: Methods and available software. Int. J. of Bioelectromagnetism 10, 125–148 (2008)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Subhashis Banerjee .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer Science+Business Media Singapore

About this paper

Cite this paper

Banerjee, S., Mitra, S., Uma Shankar, B. (2017). ROI Segmentation from Brain MR Images with a Fast Multilevel Thresholding. In: Raman, B., Kumar, S., Roy, P., Sen, D. (eds) Proceedings of International Conference on Computer Vision and Image Processing. Advances in Intelligent Systems and Computing, vol 459. Springer, Singapore. https://doi.org/10.1007/978-981-10-2104-6_23

Download citation

  • DOI: https://doi.org/10.1007/978-981-10-2104-6_23

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-2103-9

  • Online ISBN: 978-981-10-2104-6

  • eBook Packages: EngineeringEngineering (R0)

Publish with us

Policies and ethics