Skip to main content

Hemispheric Asymmetry of the Functional Brain Connectome

  • Conference paper
  • First Online:

Part of the book series: Communications in Computer and Information Science ((CCIS,volume 710))

Abstract

Researches of neuroimaging have revealed that there are many differences between left hemisphere and right hemisphere both in anatomical structure and in cognitive function. However, little is known about the topological organization of the functional networks of the two hemispheres. In the present study, we used functional magnetic resonance imaging to examine the topological organization and hemispheric differences in the functional networks in the two hemispheres. Analysis of asymmetry on functional networks was performed on a group of 192 healthy right-handed Chinese subjects. It revealed that both left and right hemisphere showed small-worldness features. We also found a significant rightward asymmetry on clustering coefficients and characteristic path length, a significant leftward asymmetry on global efficiency. In addition, the right hemisphere shows a stronger tendency of organizational modularity. These results may explain some differences in behaviors and cognition.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Toga, A.W., Thompson, P.M.: Mapping brain asymmetry. Nat. Rev. Neurosci. 4, 37–48 (2003)

    Article  Google Scholar 

  2. Smith, D.V., Clithero, J.A., Rorden, C., Karnath, H.O.: Decoding the anatomical network of spatial attention. Proc. Nat. Acad. Sci. USA 110, 1518–1523 (2013)

    Article  Google Scholar 

  3. Halligan, P.W., Fink, G.R., Marshall, J.C., Vallar, G.: Spatial cognition: evidence from visual neglect. Trends Cogn. Sci. 7, 125–133 (2003)

    Article  Google Scholar 

  4. Reijneveld, J.C., Ponten, S.C., Berendse, H.W., Stam, C.J.: The application of graph theoretical analysis to complex networks in the brain. Clin. Neurophysiol. 118, 2317–2331 (2007)

    Article  Google Scholar 

  5. He, Y., Evans, A.: Graph theoretical modeling of brain connectivity. Curr. Opin. Neurol. 23, 341–350 (2010)

    Google Scholar 

  6. Li, M., Chen, H., Wang, J., Liu, F., Long, Z., Wang, Y., Iturria-Medina, Y., Zhang, J., Yu, C., Chen, H.: Handedness-and hemisphere-related differences in small-world brain networks: a diffusion tensor imaging tractography study. Brain Connectivity 4, 145–156 (2014)

    Article  Google Scholar 

  7. Iturria-Medina, Y., Perez Fernandez, A., Morris, D.M., Canales-Rodriguez, E.J., Haroon, H.A., Garcia Penton, L., Augath, M., Galan Garcia, L., Logothetis, N., Parker, G.J., Melie-Garcia, L.: Brain hemispheric structural efficiency and interconnectivity rightward asymmetry in human and nonhuman primates. Cereb. Cortex 21, 56–67 (2011)

    Article  Google Scholar 

  8. Bassett, D.S., Meyer-Lindenberg, A., Achard, S., Duke, T., Bullmore, E.: Adaptive reconfiguration of fractal small-world human brain functional networks. Proc. Nat. Acad. Sci. USA 103, 19518–19523 (2006)

    Article  Google Scholar 

  9. He, Y., Chen, Z., Evans, A.: Structural insights into aberrant topological patterns of large-scale cortical networks in Alzheimer’s disease. J. Neurosci. 28, 4756–4766 (2008)

    Article  Google Scholar 

  10. Tian, L., Wang, J., Yan, C., He, Y.: Hemisphere-and gender-related differences in small-world brain networks: a resting-state functional MRI study. Neuroimage 54, 191–202 (2011)

    Article  Google Scholar 

  11. Caeyenberghs, K., Leemans, A.: Hemispheric lateralization of topological organization in structural brain networks. Hum. Brain Mapp. 35, 4944–4957 (2014)

    Article  Google Scholar 

  12. Newman, M.E., Girvan, M.: Finding and evaluating community structure in networks. Phys. Rev. E: Stat., Nonlin, Soft Matter Phys. 69, 026113 (2004)

    Article  Google Scholar 

Download references

Acknowledgments

This work was supported by the National Natural Science Foundation of China (61503272, 61373101) and Postdoctoral Science Foundation of Shanxi Medical University.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Bin Wang .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer Nature Singapore Pte Ltd.

About this paper

Cite this paper

Shang, W. et al. (2017). Hemispheric Asymmetry of the Functional Brain Connectome. In: Sun, F., Liu, H., Hu, D. (eds) Cognitive Systems and Signal Processing. ICCSIP 2016. Communications in Computer and Information Science, vol 710. Springer, Singapore. https://doi.org/10.1007/978-981-10-5230-9_52

Download citation

  • DOI: https://doi.org/10.1007/978-981-10-5230-9_52

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-5229-3

  • Online ISBN: 978-981-10-5230-9

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics