Summary
A model of angiogenin has been prepared by homology modelling, based upon the structure of ribonuclease A. This model has been used to postulate an inhibitor based upon the angiostatic agent TAN1120. The complex of ribonuclease A with a dinucleotide has been modelled and used as a guide to the binding orientation of daunomycin—the closest TAN1120 analogue for which the crystal structure and stereochemistry are available.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Fett, J.W., Strydon, D.J., Lobb, R.R., Alderman, E.M., Bethume, J.L., Riordan, J.F. and Vallee, B.L., Biochemistry, 24 (1985) 5480.
Shapiro, R., Riordan, J.F. and Vallee, B.L., Biochemistry, 25 (1986) 3527.
Shapiro, R. and Vallee, B.L., Biochemistry, 28 (1989) 7401.
Klagsbrun, M. and D'Amore, P.A., Annu. Rev. Physiol. 53 (1991) 217.
Kanamaru, T., Nozaki, Y. and Masayuki, M., European Patent Application No. 89123719, 1989.
Acharya, K.R., Subramanian, V., Shapiro, R., Riordan, J.F. and Vallee, B.L., J. Mol. Biol., 228 (1992) 1269.
Brooks, B.R., Bruccoleri, R.E., Olafson, B.D., States, D.J., Swaminathan, S. and Karplus, M., J. Comput. Chem., 4 (1983) 8234.
Howlin, B.J., Harris, G.W., Moss, D.S. and Palmer, R.A., Brookhaven Data Bank entry 3rn3, Acta Crystallogr., A45 (1989) 851.
Abola, E.E., Bernstein, F.C., Bryant, S.H., Koetzle, T.F. and Weng, J., In Allen, F.H., Bergerhoff, G. and Sievers, R. (Eds.) Crystallographic databases—Information Content, Software Systems, Scientific Applications, Data Commission of the International Union of Crystallography, Cambridge, 1987, pp. 107–132.
Bernstein, F.C., Koetzle, T.F., Williams, G.J.B., MeyerJr., E.F., Brice, M.D., Rodgers, J.R., Kennard, O., Shimanouchi, T. and Tasumi, M., J. Mol. Biol. 112 (1977) 535.
Palmer, K.A., Scheraga, H.A., Riordan, J.F. and Vallee, B.L., Proc. Natl. Acad. Sci. USA, 83 (1986) 1965.
Chou, P.Y. and Fasman, G.D., Adv. Enzymol., 47 (1978) 45.
Laskowski, R.A., MacArthur, M.W., Moss, D.S. and Thornton, J.M., J. Appl. Crystallogr., 26 (1993) 283.
Borah, B., Chen, C.-W., Egan, W., Miller, M., Wlodawer, A. and Cohen, J.S., Biochemistry, 24 (1985) 2058.
Meng, E.C., Shoichet, B.K. and Kuntz, I.D., J. Comput. Chem., 13 (1992) 505.
Pares, X., Nogues, M.V., De, Lorens, R. and Cuchillo, C.M., Essays Biochem., 26 (1991) 89.
Courseilles, C., Busetta, B., Geoffre, S. and Hospital, M., Acta Crystallogr., B35 (1979) 764.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Howlia, B.J., Tomkinson, N.P., Chen, J. et al. Design of potential angiogenin inhibitors. J Computer-Aided Mol Des 8, 223–230 (1994). https://doi.org/10.1007/BF00126741
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00126741