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Investigation of the role of interneurons and their modulation by centrifugal fibers in a neural model of the olfactory bulb

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Abstract

Olfactory bulb processing results from the interaction of relay neurons with two main categories of interneurons which mediate inhibition in two distinct layers: periglomerular cells and granule cells. We present here a neural model of the mammalian olfactory bulb which allows to separately investigate the functional consequences of the two types of interneurons onto the relay neurons responsiveness to odors. The model, although built with simplified representations of neural elements generates various aspects of neural dynamics from the cellular to the populational level. We propose that the combined action of centrifugal control at two different layers of processing is complementary: reduction of the number of active relay neurons responding to a given odorant through increased activity of periglomerular cells, and an increase of response intensity of active mitral cells through decrease of granule cell inhibition.

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Authors and Affiliations

  1. Dept. of Psychology, Harvard University, 33, Kirkland Street, 02138, Cambridge, MA

    Christiane Linste

  2. Laboratoire Physiologie Neurosensorielle, CNRS (URA 180), Université Claude Bernard Lyonl, F-69622, Villeurbanne, France

    Rémi Gervais

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  1. Christiane Linste
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  2. Rémi Gervais
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Linste, C., Gervais, R. Investigation of the role of interneurons and their modulation by centrifugal fibers in a neural model of the olfactory bulb. J Comput Neurosci 3, 225–246 (1996). https://doi.org/10.1007/BF00161133

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  • DOI: https://doi.org/10.1007/BF00161133

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