Uncovering the synchronization dynamics from correlated neuronal activity quantifies assembly formation

Abstract

Synchronous network excitation is believed to play an outstanding role in neuronal information processing. Due to the stochastic nature of the contributing neurons, however, those synchronized states are difficult to detect in electrode recordings. We present a frame-work and a model for the identification of such network states and of their dynamics in a specific experimental situation. Our approach operationalizes the notion of neuronal groups forming assemblies via synchronization based on experimentally obtained spike trains. The dynamics of such groups is reflected in the sequence of synchronized states, which we describe as a renewal dynamics. We furthermore introduce a rate function which is dependent on the internal network phase that quantifies the activity of neurons contributing to the observed spike train. This constitutes a hidden state model which is formally equivalent to a hidden Markov model, and all its parameters can be accurately determined from the experimental time series using the Baum-Welch algorithm. We apply our method to recordings from the cat visual cortex which exhibit oscillations and synchronizations. The parameters obtained for the hidden state model uncover characteristic properties of the system including synchronization, oscillation, switching, back-ground activity and correlations. In applications involving multielectrode recordings, the extracted models quantify the extent of assembly formation and can be used for a temporally precise localization of system states underlying a specific spike train.