Abstract
A computational model of long-term potentiation (LTP) and long-term depression (LTD) in the hippocampus is presented. The model assumes the existence of retrograde signals, is in good agreement with several experimental data on LTP, LTD, and their pharmacological manipulations, and shows how a simple kinetic scheme can capture the essential characteristics of the processes involved in LTP and LTD. We propose that LTP and LTD could be two different but conceptually similar processes, induced by the same class of retrograde signals, and maintained by two distinct mechanisms. An interpretation of a number of experiments in terms of the molecular processes involved in LTP and LTD induction and maintenance, and the roles of a retrograde signal are presented and discussed.
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References
Bienenstock EL, Cooper LN, Munro PW (1982) Theory for the development of neuron selectivity: Orientation specificity and binocular interaction in visual cortex.J. Neurosci. 2:32–48.
Bliss TVP, Lomo T (1973) Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.J. Physiol. 232:331–356.
Bredt DS, Snyder SH (1992) Nitric oxide: A novel neuronal messenger.Neuron 8:3–11.
Brown TH, Zador AM (1990) The Hippocampus. In: GM Shepherd, ed. The Synaptic Organization of the Brain. Oxford University Press, New York. pp. 346–388.
Dudek SM, Bear MF (1992) Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade.Proc. Natl. Acad. Sci. USA 89:4363–4367.
Dundwiddie T, Lynch GS (1978) Long-term potentiation and depression of synaptic response in rat hippocampus: localization and frequency dependence.J. Physiol. 276:353–368.
Edelstein-Keshet L (1988) Mathematical models in biology. Random House, New York.
Haley JE, Wilcox GL, Chapman PF (1992) The role of nitric oxide in hippocampal long-term potentiation.Neuron 8:211–216.
Izumi Y, Clifford DB, Zorumski CF (1992) Inhibition of long-term potentiation by NMDA-mediated nitric oxide release.Science 257:1273–1276.
Lisman J (1989) A mechanism for the Hebb and the anti-Hebb process underlying learning and memory.Proc. Natl, Acad. Sci. USA 86:9574–9578.
Malenka RC (1993) Long-term depression: Not so depressing after all.Proc. Natl. Acad. Sci. USA 90:3121–3123.
Migliore M, Ayala GF (1993) A kinetic model of short- and long-term potentiation.Neural Comput. 5:636–647.
O'Dell TJ, Hawkins RD, Kandel ER, Arancio O (1991) Tests of the roles of two diffusible substances in long-term potentiation: evidence for nitric oxide as a possible early retrograde messenger.Proc. Natl. Acad. Sci. USA 88:11285–11289.
Schuman M, Madison DV (1991) A requirement for the intercellular messenger nitric oxide in long-term potentiation.Science 254:1503–1506.
Segel Lee A (1991) Biological Kinetics, Cambridge University Press, Cambridge.
Shibuki K, Okada D (1991) Endogenous nitric oxide release required for long-term synaptic depression in the cerebellum.Nature 349:326–328.
Stevens CF, Wang Y (1993) Reversal of long-term potentiation by inhibitors of haem oxygenase.Nature 364:147–149.
Verma A, Hirsch DJ, Glatt CE, Ronnett GV, Snyder SH (1993) Carbon monoxide: A putative neural messenger.Science 259:381–384.
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Migliore, M., Alicata, F. & Ayala, G.F. A model for long-term potentiation and depression. J Comput Neurosci 2, 335–343 (1995). https://doi.org/10.1007/BF00961444
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DOI: https://doi.org/10.1007/BF00961444