Abstract
With the advances in technology, assistive medical systems are emerging with rapid growth and helping healthcare professionals. The proactive diagnosis of diseases with artificial intelligence (AI) and its aligned technologies has been an exciting research area in the last decade. Doctors usually detect tuberculosis (TB) by checking the lungs’ X-rays. Classification using deep learning algorithms is successfully able to achieve accuracy almost similar to a doctor in detecting TB. It is found that the probability of detecting TB increases if classification algorithms are implemented on segmented lungs instead of the whole X-ray. The paper’s novelty lies in detailed analysis and discussion of U-Net + + results and implementation of U-Net + + in lung segmentation using X-ray. A thorough comparison of U-Net + + with three other benchmark segmentation architectures and segmentation in diagnosing TB or other pulmonary lung diseases is also made in this paper. To the best of our knowledge, no prior research tried to implement U-Net + + for lung segmentation. Most of the papers did not even use segmentation before classification, which causes data leakage. Very few used segmentations before classification, but they only used U-Net, which U-Net + + can easily replace because accuracy and mean_iou of U-Net + + are greater than U-Net accuracy and mean_iou , discussed in results, which can minimize data leakage. The authors achieved more than 98% lung segmentation accuracy and mean_iou 0.95 using U-Net + + , and the efficacy of such comparative analysis is validated.


























Similar content being viewed by others
Explore related subjects
Discover the latest articles and news from researchers in related subjects, suggested using machine learning.Data availability
It is confirmed by the authors that data supporting this research finding are present within the article, and the publicly available datasets used in this study are Montgomery County X-ray Set and Shenzhen Hospital X-ray Set [36].
References
Global Tuberculosis Report (2019) WHO. World Health Organization, Switzerland
World Health Organization (2016) Chest radiography in tuberculosis detection: summary of current WHO recommendations and guidance on programmatic approaches. World Health Organization, Geneva
Brady AP (2017) Error and discrepancy in radiology: Inevitable or avoidable? Insights Image 8(1):171–182
Degnan AJ, Ghobadi EH, Hardy P, Krupinski E, Scali EP, Stratchko L, Ulano A, Walker E, Wasnik AP, Auffermann WF (2019) Perceptual and interpretive error in diagnostic radiology—causes and potential solutions. Acad Radiol 26(6):833–845
van Cleeff M, Kivihya-Ndugga L, Meme H, Odhiambo J, Klauser P (2005) The role and performance of chest X-ray for the diagnosis of tuberculosis: a cost-effectiveness analysis in Nairobi, Kenya. BMC Infect Dis 5(1):111
Graham S, Gupta KD, Hidvegi JR, Hanson R, Kosiuk J, Zahrani KA, Menzies D (2002) Chest radiograph abnormalities associated with tuberculosis: reproducibility and yield of active cases. Int J Tuberc Lung Dis 6(2):137–142
Shin H-C, Roth HR, Gao M, Lu L, Xu Z, Nogues I, Yao J, Mollura D, Summers RM (2016) Deep convolutional neural networks for computer-aided detection: CNN architectures, dataset characteristics, and transfer learning. IEEE Trans Med Imag 35(5):1285–1298
Ravishankar H et al (2016) Understanding the mechanisms of deep transfer learning for medical images. In: Carneiro G (ed) Deep learning and data labeling for medical applications. DALMIA, LABELS (lecture notes in computer science), vol 10008. Springer, Cham. https://doi.org/10.1007/978-3-319-46976-8_20
Zhou L, Ampon-Wireko S, Asante Antwi H et al (2020) An empirical study on the determinants of health care expenses in emerging economies. BMC Health Serv Res 20:774. https://doi.org/10.1186/s12913-020-05414-z
Joseph B, Joseph M (2016) The health of the healthcare workers. Indian J Occup Environ Med 20(2):71–72. https://doi.org/10.4103/0019-5278.197518
Krizhevsky A, Sutskever I, Hinton GE (2012) Imagenet classification with deep convolutional neural networks. In: Proc. Adv. Neural Inf. Process. Syst. (NIPS), pp. 1097–1105
Rahman T, Khandakar A, Kadir M, Islam K, Islam K, Mazhar R, Hamid T, Islam M, Kashem S, Ayari M, Chowdhury M (2020) Reliable tuberculosis detection using chest x-ray with deep learning, segmentation, and visualization. IEEE Access 8:191586–191601. https://doi.org/10.1109/ACCESS.2020.3031384
Tahir A, Qiblawey Y, Khandakar A, Rahman T, Khurshid U, Musharavati F, Islam MT, Kiranyaz S, Chowdhury MEH (2020) Coronavirus: comparing COVID-19, SARS and MERS in the eyes of AI. . [Online]. Available: http://arxiv.org/abs/2005.11524
Narin A, Kaya C, Pamuk Z (2020) Automatic detection of coronavirus disease (COVID-19) using X-ray images and deep convolutional neural networks. arXiv 2020, http://arxiv.org/abs/2003.10849
Chhikara P, Singh P, Gupta P, Bhatia T (2020) Deep convolutional neural network with transfer learning for detecting pneumonia on chest X-rays. In: Jain L, Virvou M, Piuri V, Balas V (eds) Advances in bioinformatics, multimedia, and electronics circuits and signals (advances in intelligent systems and computing), vol 1064. Springer, Singapore. https://doi.org/10.1007/978-981-15-0339-9_13
Zak M, Krzyżak A (2020) Classification of lung diseases using deep learning models. In: Krzhizhanovskaya VV (ed) Computational science—ICCS 2020. ICCS 2020. Lecture notes in computer science, vol 12139. Springer, Cham. https://doi.org/10.1007/978-3-030-50420-5_47
Hooda R, Mittal A, Sofat S, Automated TB (2019) classification using an ensemble of deep architectures. Multimed Tools Appl 78:31515–31532
Melendez J, Sánchez CI, Philipsen RH, Maduskar P, van Ginneken B (2014) 'Multiple-instance learning for computer-aided detection of tuberculosis. Proc. SPIE, vol. 9035
Hooda R, Sofat S, Kaur S, Mittal A, Meriaudeau F (2017) Deep-learning: a potential method for tuberculosis detection using chest radiography. In: Proc. IEEE Int. Conf. Signal Image Process. Appl. (ICSIPA), Kuching, Malaysia, pp. 497–502
Rohilla A, Hooda R, Mittal A (2017) Tb detection in chest radiograph using deep learning architecture. Proc ICETETSM 6(8):1073–1085
Evangelista LGC, Guedes EB (2018) Computer-aided tuberculosis detection from chest X-ray images with convolutional neural networks. In: Proc. Anais do XV Encontro Nacional de Inteligência Artif. e Computacional (ENIAC), pp. 518–527
Pasa F, Volkov V, Pfeiffer F, Cremers D, Pfeiffer D (2019) Efficient deep network architectures for fast chest X-ray tuberculosis screening and visualization. Sci Rep 9(1):1–9
Nguyen QH, Nguyen BP, Dao SD, Unnikrishnan B, Dhingra R, Ravichandran SR, Satpathy S, Raja PN, Chua MCH (2019) Deep learning models for tuberculosis detection from chest X-ray images. In: Proc. 26th Int. Conf. Telecommun. (ICT), pp. 381–386
Lopes UK, Valiati JF (2017) Pre-trained convolutional neural networks as feature extractors for tuberculosis detection. Comput Biol Med 89:135–143
Meraj SS, Yaakob R, Azman A, Rum SN, Shahrel A, Nazri A, Zakaria NF (2019) Detection of pulmonary tuberculosis manifestation in chest X-rays using different convolutional neural network (CNN) models. Int J Eng Adv Technol (IJEAT) 9(1):2270–2275
Ahsan M, Gomes R, Denton A (2019) Application of a convolutional neural network using transfer learning for tuberculosis detection. In: Proc. IEEE Int. Conf. Electro Inf. Technol. (EIT), pp. 427–433
Yadav O, Passi K, Jain CK (2018) Using deep learning to classify X-ray images of potential tuberculosis patients. In: Proc. IEEE Int. Conf. Bioinf. Biomed. (BIBM), pp. 2368–2375
Ardila D, Kiraly AP, Bharadwaj S, Choi B, Reicher JJ, Peng L, Tse D, Etemadi M, Ye W, Corrado G et al (2019) End-to-end lung cancer screening with deep three-dimensional learning on low-dose chest computed tomography. Nat Med 25:954–961
Ausawalaithong W, Thirach A, Marukatat S, Wilaiprasitporn T (2018) Automatic lung cancer prediction from chest X-ray images using the deep learning approach. In: Proceedings of the 2018 11th biomedical engineering international conference (BMEiCON), Chiang Mai, Thailand, pp. 21–24
Hua KL, Hsu CH, Hidayati SC, Cheng WH, Chen YJ (2015) Computer-aided classification of lung nodules on computed tomography images via deep learning technique. OncoTargets Ther 8:2015–2022
Islam MZ, Islam MM, Asraf A (2020) A combined deep CNN-LSTM network for the detection of novel coronavirus (COVID-19) using X-ray images. Inf Med Unlocked 20:100412
Kermany D, Goldbaum M (2018) Labeled optical coherence tomography (oct) and chest x-ray images for classification. Mendeley Data 2
Ronneberger O, Fischer P, Brox T (2015) U-Net: Convolutional networks for biomedical image segmentation. In: Navab N, Hornegger J, Wells W, Frangi A (eds) Medical image computing and computer-assisted intervention—MICCAI 2015. MICCAI 2015. Lecture notes in computer science, vol 9351. Springer, Cham. https://doi.org/10.1007/978-3-319-24574-4_28
Zhou Z, Rahman Siddiquee MM, Tajbakhsh N, Liang J (2018) UNet++: a nested U-Net architecture for medical image segmentation. In: Stoyanov D (ed) Deep learning in medical image analysis and multimodal learning for clinical decision support. DLMIA 2018, ML-CDS 2018. Lecture notes in computer science, vol 11045. Springer, Cham. https://doi.org/10.1007/978-3-030-00889-5_1
Badrinarayanan V, Kendall A, Cipolla R (2017) SegNet: a deep convolutional encoder-decoder architecture for image segmentation. IEEE Trans Pattern Anal Mach Intell 39(12):2481–2495. https://doi.org/10.1109/TPAMI.2016.2644615
Jaeger S, Candemir S, Antani S, Wáng Y-X, Pu-Xuan Lu (2014) Two public chest X-ray datasets for computer-aided screening of pulmonary diseases. Quant Imaging Med Surg 4(6):475–477. https://doi.org/10.3978/j.issn.2223-4292.2014.11.20
Long J, Shelhamer E, Darrell T (2015) Fully convolutional networks for semantic segmentation. CVPR. https://doi.org/10.1109/CVPR.2015.7298965
Guo R, Passi K, Jain CK (2020) Tuberculosis diagnostics and localization in chest X-rays via deep learning models. Front Artif Intell 3:583427. https://doi.org/10.3389/frai.2020.583427
Ting P, Guo S, Zhang X, Zhao L (2019) Automatic lung segmentation based on texture and deep features of HRCT images with interstitial lung disease. Biomed Res Int. https://doi.org/10.1155/2019/2045432
Zhao C, Xu Y, He Z, Tang J, Zhang Y, Han J, Shi Y, Zhou W (2021) Lung segmentation and automatic detection of COVID-19 using radiomic features from chest CT images. Pattern Recognit 119:108071. https://doi.org/10.1016/j.patcog.2021.108071
Monshi MM, Poon J, Chung V, Monshi FM (2021) CovidXrayNet: optimizing data augmentation and CNN hyperparameters for improved COVID-19 detection from CXR. Comput Biol Med. https://doi.org/10.1016/j.compbiomed.2021.104375
Diniz JOB, Quintanilha DBP, Santos Neto AC et al (2021) Segmentation and quantification of COVID-19 infections in CT using pulmonary vessels extraction and deep learning. Multimed Tools Appl 80:29367–29399. https://doi.org/10.1007/s11042-021-11153-y
Cao F, Zhao H (2021) Automatic lung segmentation algorithm on chest X-ray images based on fusion variational auto-encoder and three-terminal attention mechanism. Symmetry 13(5):814. https://doi.org/10.3390/sym13050814
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflicts of interest
The authors declare no conflict of interest.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Gite, S., Mishra, A. & Kotecha, K. Enhanced lung image segmentation using deep learning. Neural Comput & Applic 35, 22839–22853 (2023). https://doi.org/10.1007/s00521-021-06719-8
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00521-021-06719-8
Keywords
Profiles
- Ketan Kotecha View author profile