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Dynamical synaptic plasticity: a model and connection to some experiments

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Abstract.

 Using a modified version of a phenomenological model for the dynamics of synaptic plasticity, we examine some recent experiments of Wu et al. [(2001) J Physiol 533:745–755]. We show that the model is quantitatively consistent with their experimental protocols producing long-term potentiation (LTP) and long-term depression (LTD) in slice preparations of rat hippocampus. We also predict the outcome of similar experiments using different frequencies and depolarization levels than reported in their results.

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Authors and Affiliations

  1. Institute for Nonlinear Science, University of California, San Diego, CA 92093-0402, USA, , , , , , US

    A. Whitehead, M. I. Rabinovich & R. Huerta

  2. Department of Physics, MC 103-33, California Institute of Technology, Pasadena, CA 91125, USA, , , , , , US

    V. P. Zhigulin

  3. Institute for Nonlinear Science, Marine Physical Laboratory (Scripps Institution of Oceanography) and Department of Physics, University of California, San Diego, La Jolla, CA 93093-0402, USA, , , , , , US

    Henry D. I. Abarbanel

Authors
  1. A. Whitehead
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  2. M. I. Rabinovich
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  3. R. Huerta
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  4. V. P. Zhigulin
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  5. Henry D. I. Abarbanel
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Additional information

Received: 3 September 2002 / Accepted in revised form: 22 October 2002 / Published online: 24 February 2003

Correspondence to: H.D.I. Abarbanel (e-mail: hdia@jacobi.ucsd.edu)

Acknowledgements. We are very grateful to A. Selverston and D. Feldman for conversations about this work. This work was partially supported by the U.S. Department of Energy, Office of Basic Energy Sciences, Division of Engineering and Geosciences, under grants No. DE-FG03-90ER14138 and No. DE-FG03-96ER14592, by a grant from the National Science Foundation, NSF PHY0097134, by a grant from the Army Research Office, DAAD19-01-1-0026, by a grant from the Office of Naval Research, N00014-00-1-0181, and by a grant from the National Institutes of Health, NIH R01 NS40110-01A2. This work was also partially supported by M. Ciencia y Tecnologa BFI2000-0157 (R.H.).

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Whitehead, A., Rabinovich, M., Huerta, R. et al. Dynamical synaptic plasticity: a model and connection to some experiments. Biol. Cybern. 88, 229–235 (2003). https://doi.org/10.1007/s00422-002-0376-4

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  • DOI: https://doi.org/10.1007/s00422-002-0376-4

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