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Intrinsic versus extrinsic influences in the development of neuronal maps

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Abstract

Accumulating evidence suggests that the plasticity of extrinsic thalamocortical inputs in cortical layer IV may be guided or instructed by earlier plasticity events in the intrinsic, horizontal connections within the extragranular cortical layers. We analyse a rate-based model of the plasticity of a set of extrinsic afferents in the presence of a pre-existing (and fixed) plexus of intrinsic, overall excitatory horizontal connections between a set of target neurons. We determine conditions under which afferent synaptic pattern formation respects this pre-existing lateral structure. We find three broad regimes under which extrinsic afferent plasticity may violate this structure: the initial pattern of extrinsic afferent innervation of the target cells is far from balanced; the gain of the extrinsic afferents greatly exceeds the overall scale of the strength of lateral excitation; the target cell horizontal coupling matrix is sparse. If none of these conditions is satisfied, then extrinsic afferent plasticity respects the pre-existing lateral connectivity, so that afferent synaptic pattern formation conforms to the pattern of lateral excitation.

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  1. Department of Electronics and Computer Science, University of Southampton, Highfield, Southampton, SO17 1BJ, UK

    Terry Elliott

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  1. Terry Elliott
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Correspondence to Terry Elliott.

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Elliott, T. Intrinsic versus extrinsic influences in the development of neuronal maps. Biol Cybern 96, 129–143 (2007). https://doi.org/10.1007/s00422-006-0103-7

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  • DOI: https://doi.org/10.1007/s00422-006-0103-7

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