Skip to main content

Advertisement

Log in

Validating concepts of mental disorder: precedents from the history of science

  • Prospects
  • Published:
Biological Cybernetics Aims and scope Submit manuscript

Abstract

A fundamental issue in any branch of the natural sciences is validating the basic concepts for use in that branch. In psychiatry, this issue has not yet been resolved, and indeed, the proper nature of the problem has scarcely been recognised. As a result, psychiatry (or at least those parts of the discipline which aspire to scientific status) still cannot claim to be a part of scientific medicine, or to be incorporated within the common language of the natural sciences. While this creates difficulties within the discipline, and its standing in relation to other branches of medicine, it makes it an exciting place for “frontiersmen” (and women). This is one of the key growing points in the natural science tradition. In this essay, which moves from the early history of that tradition to today’s debates in scientific psychiatry, I give my views about how these fundamental issues can move towards resolution.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

Notes

  1. Since Bacon is here standing judge over the relative merits of experimental evidence and reason, he can use neither approach as a basis for making the comparison. Here, as often in his writings, he uses a third style of rhetoric, by metaphor or analogy, arguably an older and more fundamental basis for communication than either reason or empirical evidence.

References

  • Bacon F (1620) Novum Organum. edition from Clarendon Press, Oxford (Thomas Fowler ed, 1889)

  • Bacon F (1627) The New Atlantis. In: The Advancement of learning, and The New Atlantis (Preface by Thomas Case). The World’s Classics. Oxford University Press, Oxford

  • Batty D (2002) Dangerous and severe personality disorder. Guardian, UK, 17 April

  • Beninger RJ (1983) The role of dopamine in locomotor behavior and learning. Brain Res Rev 6:173–196

    Article  CAS  Google Scholar 

  • Beninger RJ, Miller R (1998) Dopamine D1-like receptors and reward-related incentive learning. Neurosci Biobehav Rev 22:335–345

    Article  CAS  PubMed  Google Scholar 

  • Bernard C (1865) An introduction to the study of experimental medicine. English translation, Dover 1957, p 55

  • Black J (2010) In their right mind. New Zealand Listener, May 2010, pp. 8–14

  • Boyle M (2002) Schizophrenia: a scientific delusion, 2nd edn. Routledge, London

    Google Scholar 

  • Carsten E (2010) Dyslexia as disability or handicap: when does vocabulary matter? J Learn Disabil 43:469–478

    Article  Google Scholar 

  • Centers for Disease Control and Prevention (2010) Increasing prevalence of parent-reported attention deficit/hyperactivity disorder among children. MMWR 59:1439–1443

    Google Scholar 

  • Editorial (2005) Following Koch’s examples. Nature Rev Microbiol 3:906

    Google Scholar 

  • Flor-Henry HP (1969) Psychosis and temporal lobe epilepsy. A controlled investigation. Epilepsia 10:363–395

    Article  CAS  PubMed  Google Scholar 

  • Frances A (2012) Attention deficit disorder is over-diagnosed and over-treated. Huffington Post (The Blog), 3rd April, 2012

  • Frances A (2013) Saving Normal: An Insider’s Revolt Against Out-of-Control Psychiatric Diagnosis, DSM-5, Big Pharma, and the Medicalization of Ordinary Life. William Morrow, New York; see also blog entitled “Saving Normal” in Psychology Today

  • Hatcher J, Snowling MJ, Griffiths YM (2002) Cognitive assessment of dyslexic students in higher education. Br J Educ Psychol 72:119–133

    Article  PubMed  Google Scholar 

  • Josselyn SA, Miller R, Beninger RJ (1997) Behavioral effects of clozapine and dopamine receptor subtypes. Neurosci Biobehav Rev 21:531–558

    Article  CAS  PubMed  Google Scholar 

  • Koestler (1968) The Sleepwalkers. Penguin, Harmondsworth. “Like Minds Like Mine” website: http://www.likeminds.org.nz

  • Markram H, Lübke J, Froscher M, Sakmann B (1997) Regulation of synaptic efficacy by coincidence of postsynaptic APs and EPSPs. Science 275:213–215

    Google Scholar 

  • Meulders M (2010/2001; trans: L Grey) Helmholtz: from enlightenment to neuroscience. MIT Press, Cambridge, MA

  • Miller R (1975) Distribution and properties of commissural and other neurones in cat sensorimotor cortex. J Comp Neurol 164:361–374

    Google Scholar 

  • Miller R (1976) Schizophrenic psychology, associative learning and the role of forebrain dopamine. Med Hypotheses 2:203–211

    Article  CAS  PubMed  Google Scholar 

  • Miller R, Wickens JR, Beninger RJ (1990) Dopamine D-1 and D-2 receptors in relation to reward and performance: a case for the D-1 receptor as a primary site of therapeutic action of neuroleptic drugs. Prog Neurobiol 34:143–184

    Article  CAS  PubMed  Google Scholar 

  • Miller R (1991) Cortico-hippocampal interplay and the representation of contexts in the brain. Springer, Berlin

    Book  Google Scholar 

  • Miller R (1996) Axonal conduction time and human cerebral laterality. Harwood Academic Publishers, Amsterdam

    Google Scholar 

  • Miller R (2008) A neurodynamic theory of schizophrenia and their disorders. Lulu Enterprises, Morrinsville, NC

    Google Scholar 

  • Olds J, Milner PM (1954) Positive reinforcement produced by electrical stimulation of septal and other areas of rat brain. J Comp Physiol Psychol 47:419–427

    Article  CAS  PubMed  Google Scholar 

  • Read J, Mosher L, Bentall R (2004) Models of madness: Psychological, Social and Biological approaches to schizophrenia. Brunner-Routledge, Hove

    Book  Google Scholar 

  • Studdert-Kennedy M, Shankweiler D (1970) Hemispheric specialization for speech perception. J Acoust Soc Am 48:579–594

    Article  CAS  PubMed  Google Scholar 

  • Swadlow HA (2000) Information low along neocortical axons. In: Miller R (ed) Time and the Brain. Harwood Academic Publishers, Amsterdam, pp 131–155

    Chapter  Google Scholar 

  • Swadlow HA, Geschwind N, Waxman SG (1979) Commissural transmission in humans. Science 204:530–531

    Article  CAS  PubMed  Google Scholar 

  • Washington HA (2011) Deadly monopolies: The shocking corporate takeover of life itself - and the consequences for your health and our medical future. Doubleday, NewYork (especially chapter 4)

  • Young A (1995) The DSM-III revolution. Chapter 3, in The harmony of illusions: inventing post-traumatic stress disorder. Princeton University Press, Princeton, NJ

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Robert Miller.

Additional information

This paper is an expansion of a lecture I gave in Tübingen on 24th October, 2011, about six weeks after Valentin’s death. I first met him on a visit to Tübingen, in 1981, attracted by his ideas on the cerebellum, and the role of axonal conduction time in that structure. He was a man of unfailing courtesy, generosity, and wisdom, a beacon of integrity, and a fine scientist, giving rise to many interesting ideas. I also regard him as a friend and mentor, and perhaps the only person I have been able to take as a guide on how to be a scientist. He was trained as a psychiatrist before he became a neuroscientist and worked briefly at the institute in Rome, where, a few years earlier, Cerletti and Bini had developed electroconvulsive therapy. He said to me more than once that the real place where the study of brain dynamics would show that its worth was in understanding mental disorders.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Miller, R. Validating concepts of mental disorder: precedents from the history of science. Biol Cybern 108, 689–699 (2014). https://doi.org/10.1007/s00422-014-0593-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00422-014-0593-7

Keywords

Navigation