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A model of the FAD redox cycle describes the dynamics of the effect of the geomagnetic field on the human visual system

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Abstract

In experimental studies, we could show that the visual threshold of man is influenced by the geomagnetic field. One of the results was that the threshold shows periodic fluctuations when the vertical component of the field is reversed periodically. The maximum of these oscillations occurred at a period duration of 110 s. To explain this phenomenon, we chose the process that likely underlies the navigation of birds in the geomagnetic field: the light reaction of the FAD component of cryptochrome in the retina. The human retina contains cryptpochrome like the bird retina. Based on the investigations of Müller and Ahmad (J Biol Chem 286:21033–21040, 2011) and Solov’yov and Schulten (J Phys Chem B 116:1089–1099, 2012), we designed a model of the light-induced reduction and subsequent reoxidation of FAD. This model contains a radical pair, whose interconversion dynamics are affected by the geomagnetic field. The parameters of the model were partly calculated from the data of our experimental investigation and partly taken from the results of other authors. These parameters were then optimized by adjusting the model behaviour to the experimental results. The simulation of the finished model shows that the concentrations of all substances included show really oscillations with the frequency of the modelled magnetic field. After optimization of the parameters, the oscillations of FAD and FADH* show maximal amplitude at a period duration of 110 s, as was observed in the experiment. This makes it most likely that the signal, which influences the visual system, originates from FADH* (signalling state).

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Authors and Affiliations

  1. Carl-Ludwig-Institute of Physiology, University of Leipzig, Liebigstr. 27, 04103, Leipzig, Germany

    Franz Thoss & Bengt Bartsch

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  1. Franz Thoss
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  2. Bengt Bartsch
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Correspondence to Franz Thoss.

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We dedicate this paper to the memory of Professor Hans Drischel ( $$\dagger $$ † ), one of the founders of Biocybernetics in Germany and worldwide, on the occasion of his 100th birthday on June 8, 2015.

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Thoss, F., Bartsch, B. A model of the FAD redox cycle describes the dynamics of the effect of the geomagnetic field on the human visual system. Biol Cybern 111, 347–352 (2017). https://doi.org/10.1007/s00422-017-0725-y

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