Abstract
In this paper, the problem on asymptotical and robust stability of genetic regulatory networks with time-varying delays and stochastic disturbance is considered. The time-varying delays include not only discrete delays but also distributed delays. The parameter uncertainties are time-varying and norm-bounded. Based on the Lyapunov stability theory and Lur’s system approach, sufficient conditions are given to ensure the stability of genetic regulatory networks. All the stability conditions are given in terms of linear matrix inequalities, which are easy to be verified. Illustrative example is presented to show the effectiveness of the obtained results.
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References
Becskei A, Serrano L (2000) Engineering stability in gene networks by autoregulation. Nature 405(6786):590–593
Bolouri H, Davidson EH (2002) Modeling transcriptional regulatory networks. Bioessays 24(12):1118–1129
Boyd S, Ghaoui L, Feron E, Balakrishnan V (1994) Linear matrix inequalities in system and control theory. SIAM, Philadelphia
Cao JD, Ren FL (2008) Exponential stability of discrete-time genetic regulatory networks with delays. IEEE Trans Neural Netw 19(3):520–523
Chen LN, Aihara K (2002) Stability of genetic regulatory networks with time delay. IEEE Trans Circuits Syst I Fundam Theor Appl 49(5):602–608
De Jong H (2002) Modeling and simulation of genetic regulatory systems: a literature review. J Comput Biol 9(1):67–103
Elowitz MB, Leibler S (2000) A synthetic oscillatory network of transcriptional regulators. Nature 403(6767):335–338
Gahinet P, Nemirovski A, Laub A, Chialali M (1995) LMI control toolbox user’s guide.The Mathworks, Natick
Gu KQ (2000) An integral inequality in the stability problem of time-delay systems. In: Proceedings of the 39th IEEE conference on decision and control, vols 1–5, pp 2805–2810
Hasty J, McMillen D, Isaacs F, Collins JJ (2001) Computational studies of gene regulatory networks: in numero molecular biology. Nat Rev Genet 2(4):268–279
Huang H, Feng G (2007) Delay-dependent stability for uncertain stochastic neural networks with time-varying delay. Phys A Stat Mech Appl 381:93–103
Kobayashi T, Chen LN, Aihara K (2003) Modeling genetic switches with positive feedback loops. J Theor Biol 221(3):379–399
Li CD, Liao XF (2005) New exponential stability criteria for delayed neural networks. In: Proceedings of the 2005 international conference on neural networks and brain, vols 1–3, pp 183–186
Li CD, Liao XF, Wong KW (2006a) Delay-dependent and delay-independent stability criteria for cellular neural networks with delays. Int J Bifurc Chaos 16(11):3323–3340
Li CG, Chen LN, Aihara K (2006b) Stability of genetic networks with SUM regulatory logic: Lur’e system and LMI approach. IEEE Trans Circuits Syst I Regul Pap 53(11):2451–2458
Li CG, Chen LJN, Aihara K (2006c) Synchronization of coupled nonidentical genetic oscillators. Phys Biol 3(1):37–44
Liao XF, Wong KW, Wu ZF, Chen GR (2001) Novel robust stability criteria for interval-delayed Hopfield neural networks. IEEE Trans Circuits Syst I-Fundam Theor Appl 48(11):1355–1359
Liao XF, Li CD (2005) An LMI approach to asymptotical stability of multi-delayed neural networks. Phys D Nonlinear Phenom 200(1–2):139–155
Liao XF, Chen GR,Sanchez EN (2002) LMI-based approach for asymptotically stability analysis of delayed neural networks. IEEE Trans Circuits Syst I Fundam Theor Appl 49(7):1033–1039
Lou XY, Cui BT (2006) On the global robust asymptotic stability of BAM neural networks with time-varying delays. Neurocomputing 70(1–3):273–279
Oksendal B (2003) Stochastic differential equations. Springer, NewYork
Ren FL, Cao JD (2008) Asymptotic and robust stability of genetic regulatory networks with time-varying delays. Neurocomputing 71(4–6):834–842
Smolen P, Baxter DA, Byrne JH (2000) Mathematical modeling of gene networks. Neuron 26(3):567–580
Turner TE, Schnell S, Burrage K (2004) Stochastic approaches for modelling in vivo reactions. Comput Biol Chem 28(3):165–178
Wang R, Zhou T, Jing Z, Chen L (2004) Modelling periodic oscillation of biological systems with multiple timescale networks. IEE Syst Biol 1(1):71–84
Wang ZD, Shu HS, Fang JA, Liu XH (2006) Robust stability for stochastic Hopfield neural networks with time delays. Nonlinear Anal Real World Appl 7(5):1119–1128
Wang ZD, Lauria S, Fang JA, Liu XH (2007) Exponential stability of uncertain stochastic neural networks with mixed time-delays. Chaos Solitons Fractals 32(1):62–72
Yuh CH, Bolouri H, Davidson EH (1998) Genomic cis-regulatory logic: experimental and computational analysis of a sea urchin gene. Science 279(5358):1896–1902
Zhang JH, Shi P, Qiu JQ (2007) Novel robust stability criteria for uncertain stochastic Hopfield neural networks with time-varying delays. Nonlinear Anal Real World Appl 8(4):1349–1357
Acknowledgments
The authors would like to thank the reviewers and the editor for their valuable suggestions and comments which have led to a much improved paper. This work is partially supported by China Postdoctoral Science Foundation (Grant NO. 20060401018), Natural Science Foundation Project of CQ CSCT (Grant NO. 2007BB2395, 2007BB2396).
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Wang, Z., Liao, X., Mao, J. et al. Robust stability of stochastic genetic regulatory networks with discrete and distributed delays. Soft Comput 13, 1199–1208 (2009). https://doi.org/10.1007/s00500-009-0417-1
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DOI: https://doi.org/10.1007/s00500-009-0417-1