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LGTBase: LARGE-like GlcNAc Transferase Database

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Abstract

Information technology has greatly speeded up the discovery in biomedical research. However, most of the modern biomedical scientists are not familiar with the new technology. To overcome the difficulty, an intelligent information system is needed to help scientists in designing and conducting research projects. Previously, we have designed a static knowledge management system for the LARGE-like glycosyltransferase, a novel GlcNAc transferase involved in human diseases such as muscular dystrophy and human meningioma, by integrating data from public databases. According the characteristics of protein structure of LARGE protein family members include an N-terminal cytoplasmic domain, a transmembrane region, a coiled-coil motif and a putative catalytic domain with the conserved aspartate-any residue-aspartate motif and a conserved protein structural domain. In this paper, we have described an intelligent information system for the LARGE-like GlcNAc Transferase Database, by setting up an automatic updating databank for genes of the LARGE family and by integrating several bioinformatics tools which can identify characteristics structural domains of the protein family.

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Acknowledgments

The work was supported by the grant to K.Y. Hwa from the National Science Council, Taiwan (97-2320-B-027-001) and from the National Taipei University of Technology (NTUT100-140-01). The authors declare that there is no conflict of interest.

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Authors and Affiliations

  1. Department of Molecular Science and Engineering, Institute of Organic and Polymeric Materials, Centre for Biomedical Industries, National Taipei University of Technology, Taipei, Taiwan, ROC

    Kuo-Yuan Hwa

  2. Institute of Organic and Polymeric Materials, National Taipei University of Technology, Taipei, Taiwan, ROC

    Wan Man Lin

  3. Department of Molecular Science and Engineering, National Taipei University of Technology, Taipei, Taiwan, ROC

    Chueh-Pai Li

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  1. Kuo-Yuan Hwa
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  2. Wan Man Lin
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Correspondence to Kuo-Yuan Hwa.

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Hwa, KY., Lin, W.M. & Li, CP. LGTBase: LARGE-like GlcNAc Transferase Database. Soft Comput 16, 393–401 (2012). https://doi.org/10.1007/s00500-011-0723-2

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